• To assess the antitumor response of this immunotherapy regimen.
  

• To characterize the immune response (as defined in Section VII) to the tumor-pulsed dendritic cell vaccine combined with IL-2 administration in patients with metastatic colorectal cancer.
  
• To evaluate the toxicity of this treatment regimen.
  

Inclusion Criteria:

1. Patients must have metastatic colorectal cancer. Patients are eligible whether they are previously untreated or had received prior treatment.
2. Patients must have a source of autologous tumor that can be easily harvested. This includes patients with subcutaneous or cutaneous metastases, patients with easily excisable lymph nodes containing metastatic tumor, and patients with malignant pleural effusions or ascites. In addition, some patients who undergo a planned curative operation are found at that time of surgery to be unresectable and these patients could have a sample of tumor resected at that time to be eligible for this study.
3. Karnofsky performance status equal to or greater than 70%.
4. Life expectancy of at least three months.
5. Patients must have evaluable or measurable disease in addition to the disease that will be surgically removed for the purposes of formulating the autologous vaccine.

6. Adequate baseline hematopoietic function:

   1. platelet count equal to or greater than 100,000/mm3
   2. total white blood count equal to or greater than 3,000/mm3
7. Patients must not have received any antineoplastic chemotherapy or immunotherapy for the four weeks preceding entry onto the study (six weeks for nitrosoureas and mitomycin-C).
8. Patients must not have received irradiation for the four weeks prior to entry onto the study.
9. Ability to give informed consent.

Exclusion Criteria

1. Patients may not have received prior antitumor vaccines.
2. History of any autoimmune diseases (e.g. SLE, rheumatoid arthritis, myasthenia gravis).
3. Active infection (bacterial, fungal, or viral), or active bleeding (e.g. hemoptysis, GI bleeding).
4. Pregnancy or lactation; women of childbearing potential and men must use effective contraception during the course of this clinical trial.
5. Uncontrolled angina, arrhythmias, bronchospasm, hypertension, hyperglycemia or hypercalcemia.
6. History of corticosteroid use in the four weeks preceding entry onto the clinical study.
7. Patients who require corticosteroids.
8. Evidence of HIV infection or AIDS and/or testing positive for HBSAg.
9. Any medical or psychiatric illness which in the opinion of the clinical investigators would compromise the patients ability to tolerate this treatment.
10. Patients who require anticoagulation.
11. There is no exclusion for sex or ethnic background.