Impact of Exercise Training on Endothelial Function in CAD

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by University of Leipzig.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Leipzig
ClinicalTrials.gov Identifier:
NCT00176345
First received: September 11, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted
  Purpose

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.


Condition Intervention Phase
Coronary Artery Disease
Behavioral: Exercise Training
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Educational/Counseling/Training
Official Title: Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease

Resource links provided by NLM:


Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • Endothelial function

Estimated Enrollment: 20
Study Start Date: January 2001
Detailed Description:

A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.

  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • stable CAD
  • male gender

Exclusion Criteria:

  • insulin-dependent diabetes mellitus
  • significant valvular heart disease
  • smoking
  • exercise-induced myocardial ischemia
  • conditions prohibiting exercise training
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00176345

Contacts
Contact: Rainer P Hambrecht, MD ++49-341 865 ext 1428 hamr@medizin.uni-leipzig.de
Contact: Sandra Erbs, MD ++49-341 865 ext 1428 Sandra.Erbs@medizin.uni-leipzig.de

Locations
Germany
University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology Recruiting
Leipzig, Saxony, Germany, 04289
Contact: Rainer P Hambrecht, MD    ++49-341-865 ext 1428    hamr@medizin.uni-leipzig.de   
Contact: Sandra Erbs, MD    ++49-341-865 ext 1428    Sandra.Erbs@medizin.uni-leipzig.de   
Principal Investigator: Rainer P Hambrecht, MD         
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Rainer P Hambrecht, MD University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00176345     History of Changes
Other Study ID Numbers: 639/97, 157/02
Study First Received: September 11, 2005
Last Updated: September 11, 2005
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by University of Leipzig:
exercise training
endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on September 18, 2014