Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity
Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Educational/Counseling/Training
|Official Title:||Influence of Bed-Rest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity|
- Drug-induced changes of forearm blood flow
|Study Start Date:||March 2001|
|Estimated Study Completion Date:||April 2003|
In a randomized, four-phase cross-over study the effect of simulated microgravity (13 days of bed rest), energetic restriction (-25%, fat reduced), and their combination on endothelium-dependent and -independent vasodilation will be compared with ambulatory control conditions. Using venous occlusion plethysmography cumulative intraarterial dose-response curves to endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) vasodilators will be constructed in 10 healthy male volunteers before and on day 13 of each of the four intervention periods.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00175968
|DLR Institute of Aerospace Medicine|
|Cologne, North-Rhine-Westphalia, Germany, D-51170|
|Principal Investigator:||Walter E Haefeli, MD||Heidelberg University|