Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity
Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Educational/Counseling/Training
|Official Title:||Influence of Bed-Rest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity|
- Drug-induced changes of forearm blood flow
|Study Start Date:||March 2001|
|Estimated Study Completion Date:||April 2003|
In a randomized, four-phase cross-over study the effect of simulated microgravity (13 days of bed rest), energetic restriction (-25%, fat reduced), and their combination on endothelium-dependent and -independent vasodilation will be compared with ambulatory control conditions. Using venous occlusion plethysmography cumulative intraarterial dose-response curves to endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) vasodilators will be constructed in 10 healthy male volunteers before and on day 13 of each of the four intervention periods.
|DLR Institute of Aerospace Medicine|
|Cologne, North-Rhine-Westphalia, Germany, D-51170|
|Principal Investigator:||Walter E Haefeli, MD||University of Heidelberg|