Exogenous Reinfection of Tuberculosis in Taiwan

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00173433
First received: September 12, 2005
Last updated: December 20, 2005
Last verified: June 2005
  Purpose

we hypothesize that exogenous reinfection is very important in the Taiwan endemic. Therefore, we design a series of studies to evaluate the individual contribution of exogenous reinfection and endogenous reactivation in the Taiwan endemic, and to realize the impact of exogenous reinfection. First, we will identify the patients with TB relapse after complete treatment. The M. tuberculosis isolates responsible for their initial and recurrent episodes will then be genotyped to clarify the percentage of exogenous reinfection and endogenous reinfection. In addition, we will try to detect the dormant M. tuberculosis bacilli in the lung tissue from patients just finished their anti-TB treatment by using highly sensitive molecular biologic methods to show the possibility of reactivation after complete treatment is low. Finally, we will prospectively survey the health care workers in a medical center by using chest radiograph at the 3rd weeks, and tuberculin skin test at the 3rd and 11th weeks after they expose to smear-negative culture-positive cases of TB. For those with abnormal findings, surveillance sputum mycobacterial studies will be performed. Once yielding M. tuberculosis, the isolates will be genotyped and compare with the DNA fingerprints of the index cases to demonstrate the transmission of TB.


Condition
Tuberculosis

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: The Importance of Exogenous Reinfection in the Tuberculosis Endemic of Taiwan

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 150
Study Start Date: January 1999
Estimated Study Completion Date: June 2007
Detailed Description:

Tuberculosis (TB) remains the most important infectious disease in the world. In Taiwan, the incidence of TB increased in recent years. The failure of control implies the necessity to reevaluate the epidemiology of Mycobacterium tuberculosis. It is widely thought that most cases of TB are caused by reactivation of a latent infection. Treatment programs have therefore focused on cure rates rather than tracking of additional cases. But recent studies showed that exogenous reinfection plays an important role in the development of TB. In addition, it seems that the higher the local incidence, the more important exogenous reinfection is. The question of exogenous reinfection versus endogenous reactivation has an impact on the distribution of resources for the prevention and treatment of TB. Based on these evidences, we hypothesize that exogenous reinfection is very important in the Taiwan endemic. Therefore, we design a series of studies to evaluate the individual contribution of exogenous reinfection and endogenous reactivation in the Taiwan endemic, and to realize the impact of exogenous reinfection. First, we will identify the patients with TB relapse after complete treatment. The M. tuberculosis isolates responsible for their initial and recurrent episodes will then be genotyped to clarify the percentage of exogenous reinfection and endogenous reinfection. In addition, we will try to detect the dormant M. tuberculosis bacilli in the lung tissue from patients just finished their anti-TB treatment by using highly sensitive molecular biologic methods to show the possibility of reactivation after complete treatment is low. Finally, we will prospectively survey the health care workers in a medical center by using chest radiograph at the 3rd weeks, and tuberculin skin test at the 3rd and 11th weeks after they expose to smear-negative culture-positive cases of TB. For those with abnormal findings, surveillance sputum mycobacterial studies will be performed. Once yielding M. tuberculosis, the isolates will be genotyped and compare with the DNA fingerprints of the index cases to demonstrate the transmission of TB.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • culture-proven tuberculosis with recurrence
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00173433

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Jann-Yuan Wang, MD    886-2-2356-2905    jywang@ntu.edu.tw   
Contact: Pan-Chyr Yang, PhD    886-2-2356-2905    pcyang@ha.mc.ntu.edu.tw   
Principal Investigator: Jann-Yuan Wang, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Jann-Yuan Wang, MD National Taiwan University Hospital
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00173433     History of Changes
Other Study ID Numbers: 9461700627
Study First Received: September 12, 2005
Last Updated: December 20, 2005
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
tuberculosis
relapse
reinfection
reactivation
dormancy
tuberculin skin test

Additional relevant MeSH terms:
Tuberculosis
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections

ClinicalTrials.gov processed this record on August 27, 2014