Screening for CRC Using a Mixed Strategy of Sigmoidoscopy and Colonoscopy in Average-Risk Population According to Age
Recruitment status was Recruiting
BACKGROUND: Primary screening with sigmoidoscopy would miss a substantial proportion of advanced proximal neoplasia (APN), but screening with universal colonoscopy is costly. The aim of this study is to assess the efficacy of mixed strategy which uses sigmoidoscopy for younger patients and colonoscopy for older patients.
MATERIALS and METHODS: We analyzed an established database containing consecutive average-risk adults aged 50 or older who underwent screening colonoscopy as part of health check-up. We assessed the efficacy of mixed screening strategy using colonoscopy for persons aged at and above a certain cut-off age and sigmoidoscopy for persons aged below that age. Those who underwent sigmoidoscopy initially would be referred for subsequent colonoscopy if distal sentinel lesion was detected.
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
|Official Title:||Screening for CRC Using a Mixed Strategy of Sigmoidoscopy and Colonoscopy in Average-Risk Population According to Age|
|Study Start Date:||June 2003|
|Estimated Study Completion Date:||July 2004|
Because the prevalence of proximal colon cancer and APN was higher in older patients15, a greater proportion of advanced colonic neoplasia or cancer would be missed if colonoscopy was not performed for older patients. So if we develop a mixed strategy to offer sigmoidoscopy for younger patients and reserve colonoscopy for older patients, we might be able to detect more APN with fewer colonoscopic procedures. We aimed to determine an optimal cut-off age and choose an appropriate distal sentinel lesion for subsequent colonoscopy.
|Contact: Jyh-ming Liou, MD||886-2-23123456 ext firstname.lastname@example.org|
|Departments of Internal Medicine, Medicine National Taiwan University Hospital,||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Ming-Shiang Wu, MD, PhD 886-2-23123456 ext 5695 email@example.com|
|Principal Investigator: Jyh-Ming Liou, MD|
|Principal Investigator: Shi-Pei Huang, MD,PhD|
|Sub-Investigator: Han-Mo Chiu, MD|
|Sub-Investigator: Hsiu-Po Wang, MD|
|Principal Investigator: aw-Town Lin, MD,PhD|
|Study Director:||Ming-Shiang Wu, MD, PhD||Departments of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan|