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Use of Procalcitonin in the Diagnosis of Pleural Effusion

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00172835
First received: September 12, 2005
Last updated: NA
Last verified: March 2005
History: No changes posted
  Purpose

Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.


Condition
Pleural Effusion

Study Type: Observational
Study Design: Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evaluation of Procalcitonin as a Diagnostic Tool for Patients With Pleural Effusion

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 100
Study Start Date: March 2005
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of pleural effusion
  • Pleural effusion proved by chest sonography

Exclusion Criteria:

  • Conditions for which thoracentesis are contraindicated
  • Pregnancy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00172835

Contacts
Contact: Po-Ren Hsueh, MD 886-2-2356-5363 prhsueh@ntumc.org

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Po-Ren Hsueh, MD     776-2-23565363     prhsueh@ntumc.org    
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Po-Ren Hsueh, MD Department of Laboratory Medicine, National Taiwan University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00172835     History of Changes
Other Study ID Numbers: 9461700208
Study First Received: September 12, 2005
Last Updated: September 12, 2005
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
pleural effusion
procalcitonin

Additional relevant MeSH terms:
Pleural Effusion
Pleural Diseases
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on June 17, 2013