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The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

This study has been terminated.
( Funding ended )

Sponsored by: Chinese University of Hong Kong
Information provided by: Chinese University of Hong Kong
ClinicalTrials.gov Identifier: NCT00164814
  Purpose

Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease. Despite its benign nature, this condition causes anxiety, impairs quality of life and consumes a substantial amount of healthcare resources. While acid reflux and motility disorder in the esophagus are often attributed as the cause of NCCP, visceral hyperalgesia of esophagus is now recognized to play a central role in the pathogenesis of this condition. This research project aims to evaluate the role of visceral hyperalgesia in Chinese patients with NCCP. NCCP patients will be evaluated for the prevalence of gastroesophageal reflux disease and esophageal motility disorder by endoscopy, manometry and pH study. The visceral sensory and pain thresholds of these patients will be compared with asymptomatic controls.


Condition
Non-Cardiac Chest Pain

MedlinePlus related topics:   Chest Pain    Esophagus Disorders    GERD   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Prospective
Official Title:   Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pian in Chinese? Part I: The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

Further study details as provided by Chinese University of Hong Kong:

Enrollment:   100

  Eligibility
Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Criteria

Inclusion Criteria:

  • Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
  • Age between 18-70

Exclusion Criteria:

  • Gastroesophageal reflux disease
  • Psychiatric illness
  • Cerebrovascular accident
  • Active peptic ulceration
  • Heart failure or cardiac bradyarrhythmia
  • Epilepsy
  • Pregnancy or lactating female
  • Previous hypersensitivity to muscle relaxant
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00164814

Locations
China
Endoscopy Centre, Prince of Wales Hospital    
      Hong Kong, China

Sponsors and Collaborators
Chinese University of Hong Kong

Investigators
Principal Investigator:     Justin CY WU, MD     Chinese University of Hong Kong    
  More Information

Study ID Numbers:   NPA study
First Received:   September 9, 2005
Last Updated:   March 25, 2008
ClinicalTrials.gov Identifier:   NCT00164814
Health Authority:   Hong Kong: Department of Health

Study placed in the following topic categories:
Sensation Disorders
Esophageal disorder
Gastrointestinal Diseases
Pain
Gastroesophageal Reflux
Hyperalgesia
Chest Pain
Esophageal Motility Disorders
Deglutition Disorders
Signs and Symptoms
Somatosensory Disorders
Digestive System Diseases
Neurologic Manifestations
Esophageal Diseases

Additional relevant MeSH terms:
Nervous System Diseases

ClinicalTrials.gov processed this record on September 05, 2008




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