Genetics of Alpha Thalassemia in Israeli Ethnic Groups

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Hadassah Medical Organization.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00159029
First received: September 9, 2005
Last updated: June 22, 2011
Last verified: June 2011
  Purpose

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.


Condition
Alpha Thalassemia

Study Type: Observational
Official Title: Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups

Resource links provided by NLM:


Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA

DNA isolated from peripheral blood.


Estimated Enrollment: 100
Study Start Date: April 2004
Estimated Study Completion Date: April 2012
Detailed Description:

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients who come to Hadassah Hospital for anemia with microcytosis who are found to have alpha thalassemia.

Criteria

Inclusion Criteria:

  • diagnosis of deletional alpha thalassemia

Exclusion Criteria:

  • under age 18
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00159029

Contacts
Contact: Deborah Rund, MD 00 972 2 6778712 rund@cc.huji.ac.il
Contact: Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il

Locations
Israel
Hadassah Medical Organization Recruiting
Jerusalem, Israel
Contact: Arik Tzukert, DMD    00 972 2 6776095    arik@hadassah.org.il   
Contact: Hadas Lemberg, PhD    00 972 2 6777572    lhadas@hadassah.org.il   
Principal Investigator: Deborah Rund, MD         
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
  More Information

Publications:
Responsible Party: Deborah Rund, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00159029     History of Changes
Other Study ID Numbers: 152910-HMO-CTIL
Study First Received: September 9, 2005
Last Updated: June 22, 2011
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Additional relevant MeSH terms:
Alpha-Thalassemia
Thalassemia
Anemia
Anemia, Hemolytic
Anemia, Hemolytic, Congenital
Genetic Diseases, Inborn
Hematologic Diseases
Hemoglobinopathies

ClinicalTrials.gov processed this record on October 20, 2014