Trial record 20 of 105 for:    Open Studies | "Blood Cells"

The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00155922
First received: September 9, 2005
Last updated: December 13, 2006
Last verified: September 2005
  Purpose

The investigators hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).


Condition
Diabetes Mellitus, Type 2
Atherosclerosis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Longitudinal
Official Title: The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients, Special Relevance to Atherosclerosis

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 100
Study Start Date: November 2003
Detailed Description:

Cardiovascular events are the leading cause of death in developed countries worldwide, including Taiwan. Type 2 diabetes mellitus (T2DM), previously considered merely as one of the risk factors, has been recently unanimously accepted to be coronary artery disease-equivalent. How T2DM may lead to accelerated atherosclerosis remains obscure.

Hyperglycemia with or without hyperinsulinemia may lead to higher oxidative stress and generalized inflammation. The oxidative stress and inflammation may play a significant role in the pathogenesis in diabetic complications, including micro- and macro-vascular complications. Macrophages together with T-lymphocytes are the earliest cell-types found in fatty-streaks, the earliest atherosclerotic lesions. Macrophages are also well known cellular mediators of oxidative stress and inflammation. Therefore, it is plausible to hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with T2DM. In addition, the other cell types of the peripheral white blood cells (WBC), such as neutrophils, have been shown to be intimately related to acute coronary syndrome. Therefore, the study on the biology of peripheral WBCs may tell us something about the pathophysiology of diabetic macro-vascular complications.

Methods:

  1. Normal control: fasting plasma glucose (FPG) less than 126 mg/dl.
  2. T2DM: FPG >=126 mg/dl.

    • Group 1 (good glycemic control): hemoglobin A1c (HbA1c) <= 7% in the past 6 months
    • Group 2 (poor glycemic control): HbA1c >= 8% in the past 6 months
  3. Blood sample will be collected at baseline and after aggressive control.
  Eligibility

Ages Eligible for Study:   25 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal control: fasting plasma glucose (FPG) less than 126 mg/dl.
  • T2DM: FPG >=126 mg/dl.

    • Group 1 (good glycemic control): HbA1c<=7% in the past 6 months
    • Group 2 (poor glycemic control): HbA1c>=8% in the past 6 months

Exclusion Criteria:

  • Acute systemic diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00155922

Contacts
Contact: Wei-Shiung Yang, MD, PhD 886-2-2312-3456 ext 7258 wsyang@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 10012
Contact: Wei-Shiung Yang, MD, PhD    886-2-23123456 ext 7258    wsyang@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Wei-Shiung Yang, MD, PhD National Taiwan University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00155922     History of Changes
Other Study ID Numbers: 9261700953
Study First Received: September 9, 2005
Last Updated: December 13, 2006
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Diabetes mellitus
Monocyte
Gene expression
Monocyte gene expression

Additional relevant MeSH terms:
Atherosclerosis
Arteriosclerosis
Diabetes Mellitus
Diabetes Mellitus, Type 2
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on August 01, 2014