Genomewide Screening of Pathological Myopia
Recruitment status was Recruiting
The purpose of this study is to evaluate the possible candidate gene of pathological myopia
|Study Design:||Observational Model: Case Control|
|Official Title:||Genomewide Screening of Pathological Myopia|
DNA extracted from blood
|Study Start Date:||August 2002|
|Estimated Study Completion Date:||August 2010|
|Estimated Primary Completion Date:||August 2010 (Final data collection date for primary outcome measure)|
High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.
Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.
|Contact: Yung-Feng Shih, MD||886-2-23123456 ext firstname.lastname@example.org|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 email@example.com|
|Principal Investigator:||Yung-Feng Shih, MD||National Taiwan University Hospiyal|