Genomewide Screening of Pathological Myopia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2010 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00155753
First received: September 9, 2005
Last updated: June 8, 2010
Last verified: April 2010
  Purpose

The purpose of this study is to evaluate the possible candidate gene of pathological myopia


Condition
Pathological Myopia

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Genomewide Screening of Pathological Myopia

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA

DNA extracted from blood


Estimated Enrollment: 600
Study Start Date: August 2002
Estimated Study Completion Date: August 2010
Estimated Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Detailed Description:

High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.

Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Taiwanese

Criteria

Inclusion Criteria:

  • They are unrelated Chinese subjects with high myopia ≦-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ≦-6.00 D for one eye and ≦-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected.

Exclusion Criteria:

  • Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00155753

Contacts
Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 yfshih@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yung-Feng Shih, MD    886-2-23123456 ext 5184    yfshih@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Yung-Feng Shih, MD National Taiwan University Hospiyal
  More Information

No publications provided

Responsible Party: Yung-Feng Shih, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00155753     History of Changes
Other Study ID Numbers: 9100205245
Study First Received: September 9, 2005
Last Updated: June 8, 2010
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
pathological myopia, genomic

Additional relevant MeSH terms:
Myopia
Myopia, Degenerative
Refractive Errors
Eye Diseases

ClinicalTrials.gov processed this record on July 28, 2014