Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice
Recruitment status was Recruiting
Null hypothesis of this study: Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect.
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
|Official Title:||Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice|
|Study Start Date:||April 2004|
Biliary atresia patients with cholestatic jaundice were noted to have increased incidence of infectious complications. Previous animal models of bile duct ligation with acute jaundice ever demonstrated impairment of both humoral and cellular immune function. We performed the immunity study in biliary atresia patients due to the lack of comprehensive systemic immunity study in pediatric cholestatic model. Systemic humoral immunity (total serum IgG, IgA, IgM, C3 and C4), specific cellular immunity (lymphocyte classification, mitogen response, cytokines level after PHA stimulation test), and non-specific cellular immunity (absolute neutrophil count, PMN CD11b/CD18 expression level, PMN superoxide release function, and PMN phagocytosis function) were tested. Association with serum bilirubin level, nutritional status and blood biochemical values were tested to see the relation between systemic immune function and cholestatic jaundice.
|Contact: Jia-Feng Wu, MD||886-2-23123456 ext email@example.com|
|Department of Pediatrics, National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Yen-Hsuan Ni, MD 886-2-23123456 ext 5451 firstname.lastname@example.org|
|Contact: Jia-Feng Wu, MD 886-2-23123456 ext 5451 email@example.com|
|Principal Investigator: Jia-Feng Wu, MD|
|Study Chair:||Mei-Hwei Chang, MD||Department of Pediatrics, Natonal Taiwan University Hospital|