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Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00155103
First received: September 9, 2005
Last updated: March 20, 2007
Last verified: July 2005
History of Changes
  Purpose

The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.


Condition
Hepatitis B
Carcinoma, Hepatocellular
Polymorphism, Genetic

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective
Official Title: Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 1600
Study Start Date: August 2004
Detailed Description:

We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal controls
  • Cases of chronic hepatitis and hepatocellular carcinoma

Exclusion Criteria:

  • Pregnant women
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00155103

Contacts
Contact: Li-Hui Tseng, M.D., Ph.D. +886-2-2312-3456 ext 7437 htseng@ha.mc.ntu.edu.tw
Contact: Fang-Yu Chan, B.A. +886-2-2312-3456 ext 7440 p93448006@ntu.edu.tw

Locations
Taiwan
Department of Medical Genetics; National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Li-Hui Tseng, M.D., Ph.D.     +886-2-2312-3456 ext 7437     htseng@ha.mc.ntu.edu.tw    
Contact: Fang-Yu Chan, B.A.     +886-2-2312-3456 ext 7440     p93448006@ntu.edu.tw    
Principal Investigator: Fang-Yu Chan, B.A.            
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
Investigators
Study Chair: Li-Hui Tseng, M.D., Ph.D. National Taiwan University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00155103     History of Changes
Other Study ID Numbers: 9361700927, NSC 93-2314-B-002-226
Study First Received: September 9, 2005
Last Updated: March 20, 2007
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Hepatitis B
Carcinoma, Hepatocellular
Polymorphism, Genetic

Additional relevant MeSH terms:
Carcinoma, Hepatocellular
Carcinoma
Hepatitis
Hepatitis A
Hepatitis B
Hepatitis, Chronic
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Liver Diseases
Digestive System Diseases
 Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Hepadnaviridae Infections
DNA Virus Infections
Adenocarcinoma
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site

ClinicalTrials.gov processed this record on May 23, 2013