Etiology Study of Kawasaki Disease

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 9, 2005
Last updated: August 1, 2007
Last verified: June 2005

The purpose of this study is to investigate the infectious etiology of Kawasaki disease (KD); a prospective household and case control study for Kawasaki disease will be done. The investigators will enroll Kawasaki disease cases who have at least five of the following manifestations:

  1. fever for over 5 days
  2. neck lymphadenopathy
  3. lip fissure and/or strawberry tongue
  4. skin rash
  5. nonpurulent bulbar conjunctivitis
  6. palm/sole erythema and induration followed by desquamation, or coronary artery aneurysm with less than 5 of the above manifestations (atypical Kawasaki disease)

The KD cases will receive virological (virus isolation from the blood, throat swabs and rectal swabs or stool, gene chip for possible viruses from stored RNA and DNA), bacterial (blood, throat swabs and stool: bacterial culture and stored strain for further toxin or superantigen detection), and serological (Mycoplasma pneumoniae, Chlamydiae pneumoniae, ASLO, HHV6, EV71, peptide library approach for auto-antibody or pathogen-related antibody, stored serum for further workup) workup. Stored DNA from the blood will also be performed.

Kawasaki Disease

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: Etiology Study of Kawasaki Disease--A Prospective Household and Case Control Study

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 100
Study Start Date: February 2004
Estimated Study Completion Date: June 2006
  Show Detailed Description


Ages Eligible for Study:   1 Month to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients who fulfill the criteria of Kawasaki disease or atypical Kawasaki disease and their household family members

Exclusion Criteria:

  • Not cases of Kawasaki disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00154596

Contact: Luan-Yin Chang, MD, PhD 886-2-23123456 ext 3245

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Luan-Yin Chang, MD, PhD    886-2-23123456 ext 3245   
Principal Investigator: Luan-Yin Chang, MD, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Luan-Yin Chang, MD, PhD National Taiwan University Hospital
  More Information

No publications provided Identifier: NCT00154596     History of Changes
Other Study ID Numbers: 930004318
Study First Received: September 9, 2005
Last Updated: August 1, 2007
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
etiology of disease

Additional relevant MeSH terms:
Mucocutaneous Lymph Node Syndrome
Vascular Diseases
Cardiovascular Diseases
Lymphatic Diseases
Skin Diseases, Vascular
Skin Diseases processed this record on July 22, 2014