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Stem Cell Transplantation for Patients With Hematologic Malignancies

This study has been completed.
Sponsor:
Information provided by:
St. Jude Children's Research Hospital
ClinicalTrials.gov Identifier:
NCT00152139
First received: September 8, 2005
Last updated: January 28, 2009
Last verified: January 2009
  Purpose

Childhood leukemias which cannot be cured by chemotherapy alone may be effectively treated by allogeneic bone marrow transplantation. Moreover, for patients with chronic myelogenous leukemia (CML), allogeneic hematopoietic stem cell transplantation (HSCT) is the only proven curative modality of treatment. Patients who have received hematopoietic stem cells from an HLA matched sibling donor have proven to be less at risk for disease relapse and regimen related toxicity. However, about 70% of patients in need of HSCT do not have an HLA matched sibling donor. This necessitates the search for alternative donors, which may increase the risk of a poor outcome.

The nature of the hematopoietic stem cell graft has been implicated as a primary factor determining these outcomes. The standard stem cell graft has been unmanipulated bone marrow, but recently several advantages of T-lymphocyte depleted bone marrow and mobilized peripheral blood progenitor cells (PBPC) have been demonstrated. However, T-cell depletion may increase the risk of infectious complications and leukemic recurrence while an unmanipulated stem cell graft may increase the risk of graft vs. host disease (GVHD). A key element in long range strategies in improving outcomes for patients undergoing matched unrelated donor (MUD) HSCT is to provide the optimal graft.

The primary objective of this clinical trial is to estimate the incidence of acute GVHD in pediatric patients with hematologic malignancies who receive HSCT with an unmanipulated marrow graft. The results of this study can be used as the foundation for future trials related to engineering unrelated donor graft.


Condition Intervention Phase
Acute Lymphoblastic Leukemias
Acute Myelocytic Leukemia
Chronic Myeloid Leukemia
Juvenile Myelomonocytic Leukemia
Myelodysplastic Syndrome
Hemoglobinuria, Paroxysmal
Non-Hodgkin Lymphoma
Procedure: Allogeneic Stem Cell Transplantation
Drug: Chemotherapy and antibodies
Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Hematopoietic Stem Cell Transplantation Using Matched Unrelated Donor Peripheral Blood or Bone Marrow for Patients With Hematologic Malignancies

Resource links provided by NLM:


Further study details as provided by St. Jude Children's Research Hospital:

Primary Outcome Measures:
  • To estimate the occurrence of acute graft versus host disease in patients who have received an unmanipulated hematopoietic stem cell transplant from a matched unrelated donor [ Time Frame: July 2005 ] [ Designated as safety issue: Yes ]

Enrollment: 33
Study Start Date: May 2002
Study Completion Date: January 2009
Primary Completion Date: June 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
1 Procedure: Allogeneic Stem Cell Transplantation
An infusion of HLA matched unrelated bone marrow or peripheral blood stem cells.
Other Names:
  • Allogeneic stem cell transplant
  • Matched unrelated donor stem cell transplant
  • Bone marrow stem cell transplant
Drug: Chemotherapy and antibodies
Participants received a standard conditioning regimen consisting of total body irradiation, cyclophosphamide, thiotepa and ATG. GVHD prophylaxis consisted of cyclosporine and Methotrexate.
Other Name: Graft versus host disease

Detailed Description:

Secondary outcome evaluations for this clinical study include the following:

  • To estimate the overall survival in patients with high risk hematological malignancies who receive a HSCT with an unmanipulated marrow graft or a peripheral blood stem cell graft
  • To estimate disease-free survival and relapse rates
  • To estimate the rates of chronic GvHD and graft failure
  • To estimate the incidence of non-hematologic peri-transplant regimen-related toxicity and regimen-related mortality in the first 100 days after transplantation
  • To estimate the time to neutrophil and platelet engraftment after transplantation
  • To determine the degree of NK cell and T-cell immune reconstitution at 30 days and 100 days post-transplant
  • To estimate the incidence of EBV reactivation or post-transplant lymphoproliferative disease (PTLPD)
  • To determine the pharmacokinetics of anti-thymocyte globulin (rATG) in patients receiving allogeneic transplantation and the development of rATG antibodies

Originally this study began as a randomized comparison between unmanipulated bone marrow and T-cell depleted bone marrow utilizing the investigational CliniMACS selection system. The hypothesis to be tested at the time was that the incidence of severe acute GvHD was significantly reduced in children who received HSCT with a T-cell depleted bone marrow stem cell graft as compared to those receiving an unmanipulated graft. Approximately midway through the study the evidence indicated that although the incidence of severe acute GvHD with T-cell depletion was low, it was not significantly lower than the standard treatment of unmanipulated bone marrow. Therefore the study was amended to remove the T-cell depleted arm and continue accrual to one arm providing all patients with an unmanipulated bone marrow stem cell graft. The primary objective then being to determine if the true incidence of severe acute GvHD was below 15% as reported. The observational group receiving PBPC remained open for those patients whose donors or donor centers chose to provide PBPC in lieu of bone marrow. Only one such patient was assigned to this group; therefore, no valid conclusions can be formulated.

Intervention analysis was based on those patients who received an unmanipulated stem cell product only. For this study, the investigators had requested bone marrow for all study subjects. However, the final determination of the source of the hematopoietic stem cells, bone marrow or peripheral blood, was at the discretion of the donor and the donor center. Those participants who received a peripheral blood stem cell product were followed in the observational group only. All participants, whether recipients of a bone marrow or blood stem cell product, received the same preparative conditioning regimen

  Eligibility

Ages Eligible for Study:   2 Years to 21 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All patients lacking an HLA identical sibling for whom an unrelated donor matched at 6/6 HLA loci is formally requested within about 3 months of search initiation
  • Age greater than or equal to 24 months, but less than 21 years for new patients.
  • Diagnosis of one of the following high risk hematological malignancies:
  • Acute lymphoblastic leukemia (in second or subsequent remission or high risk in first remission)
  • Acute myeloid leukemia (in relapse or remission)
  • Secondary AML/MDS
  • Chronic myeloid leukemia
  • Juvenile myelomonocytic leukemia
  • Myelodysplastic syndrome
  • Paroxysmal nocturnal hemoglobinuria
  • Non-Hodgkin's lymphoma (in second or subsequent remission)

Exclusion Criteria:

  • Patients with symptomatic cardiac disease, or evidence of significant cardiac disease by echocardiogram, or cardiac shortening fraction below 25%
  • Patients with renal creatinine clearance < 40ml/min/1.73m^2
  • Patients with FVC < 40% predicted or pulse oximetry less than or equal to 92% on room air if unable to perform pulmonary function tests
  • Patients with direct bilirubin > 3 mg/dl
  • Patients with SGPT > 500 U/L
  • Patients with a Karnofsky or Lansky performance score < 70
  • Patients who have received a previous allogeneic stem cell transplant
  • Patients with a known allergy to rabbit or murine products
  • Patients with isolated extramedullary leukemic relapse, including isolated CNS or testicular recurrence
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00152139

Locations
United States, Tennessee
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Sponsors and Collaborators
St. Jude Children's Research Hospital
Investigators
Principal Investigator: Gregory Hale, M.D. St. Jude Children's Research Hospital
  More Information

Additional Information:
No publications provided

Responsible Party: Gregory Hale, MD / Principal Investigator, St. Jude Children's Research Hospital
ClinicalTrials.gov Identifier: NCT00152139     History of Changes
Other Study ID Numbers: MUDSCT
Study First Received: September 8, 2005
Last Updated: January 28, 2009
Health Authority: United States: Food and Drug Administration

Keywords provided by St. Jude Children's Research Hospital:
High risk hematologic malignancies
Allogeneic stem cell transplant
Matched unrelated donor transplantation
Unmanipulated stem cell graft
Bone marrow transplantation

Additional relevant MeSH terms:
Hemoglobinuria
Hemoglobinuria, Paroxysmal
Leukemia
Leukemia, Lymphoid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Leukemia, Myelomonocytic, Acute
Leukemia, Myelomonocytic, Chronic
Leukemia, Myelomonocytic, Juvenile
Lymphoma, Non-Hodgkin
Myelodysplastic Syndromes
Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Preleukemia
Anemia
Anemia, Hemolytic
Bone Marrow Diseases
Hematologic Diseases
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases
Lymphoma
Lymphoproliferative Disorders
Myelodysplastic-Myeloproliferative Diseases
Myeloproliferative Disorders
Neoplasms by Histologic Type
Precancerous Conditions
Proteinuria
Signs and Symptoms

ClinicalTrials.gov processed this record on November 20, 2014