Tramadol to Reduce Opioid Withdrawal Symptoms
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Purpose
Individuals with opioid addiction often experience serious withdrawal symptoms that may make relapse unavoidable. Tramadol, a medication that is currently used to treat pain caused by chronic conditions such as cancer or joint pain, may also be effective at reducing opioid withdrawal symptoms. This study will evaluate the effectiveness of tramadol at reducing withdrawal symptoms in individuals addicted to opioid drugs.
| Condition | Intervention | Phase |
|---|---|---|
|
Opioid-Related Disorders |
Drug: Tramadol Drug: Naloxone Drug: Morphine |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Crossover Assignment Masking: Double-Blind Primary Purpose: Treatment |
| Official Title: | Withdrawal Suppression Efficacy of Tramadol |
- Opioid withdrawal symptoms (measured by Visual Analog Scale during the experimental sessions)
- Opioid agonist effects (measured by Visual Analog Scale during the experimental sessions)
- Physiological effects (measured by pulse oximeter, blood pressure, heart rate, and pupillary camera during the experimental sessions)
| Enrollment: | 16 |
| Study Start Date: | February 2005 |
| Study Completion Date: | December 2005 |
| Primary Completion Date: | December 2005 (Final data collection date for primary outcome measure) |
Opioid withdrawal symptoms are a major contributing factor for why opioid treatment programs often fail. Individuals with severe opioid withdrawal symptoms may experience shaking, muscle and bone pain, nausea, depression, anxiety, and drug craving. Tramadol is a medication that is currently used to treat moderate to severe pain in individuals with cancer, joint pain, or pain resulting from surgery. Because of its pharmacological profile, tramadol may also be useful in treating opioid withdrawal. Further research is needed to confirm the benefits of tramadol for opioid addicts. The purpose of this study is to evaluate the effectiveness of tramadol at reducing opioid withdrawal symptoms in opioid-dependent individuals.
This 6-week inpatient study will enroll opioid-dependent individuals. Participants will be required to reside at the research clinic for the entire study. All participants will receive morphine maintenance treatment on a daily basis. Twice a week participants will take part in experimental challenge sessions in which they will be randomly assigned to receive varying doses of tramadol, naloxone, morphine, or placebo. These sessions will assess the ability of tramadol to suppress opioid withdrawal symptoms. Participants will complete performance tasks to measure psychomotor and cognitive functioning. Heart rate and blood pressure will be monitored throughout the experimental sessions. A specialized camera will also be used to assess pupillary response of the eyes. Questionnaires and self-reports will be completed to assess medication effects and withdrawal symptoms. Following the end of the study, all participants will be offered outpatient drug abuse treatment.
Eligibility| Ages Eligible for Study: | 21 Years to 55 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Meets DSM-IV diagnostic criteria for opioid dependence
- Is in good physical health
- Qualifies for treatment with opioid agonist therapy (e.g., methadone)
- If female, must have a negative pregnancy test prior to study entry
Exclusion Criteria:
- Evidence of significant medical illness (e.g., insulin dependent diabetes mellitus)
- Evidence of significant psychiatric illness (e.g., schizophrenia)
- Currently seeking treatment for substance abuse
- Pregnant or breastfeeding
Contacts and Locations| United States, Maryland | |
| Johns Hopkins University (BPRU) Bayview Campus | |
| Baltimore, Maryland, United States, 21224-6823 | |
| Principal Investigator: | Eric C. Strain, MD | Johns Hopkins University |
More Information
No publications provided
| Responsible Party: | Eric C. Strain/Principal Investigator, Johns Hopkins University School of Medicine |
| ClinicalTrials.gov Identifier: | NCT00142896 History of Changes |
| Other Study ID Numbers: | NIDA-18125-1, R01-18125-1, DPMC |
| Study First Received: | September 1, 2005 |
| Last Updated: | August 14, 2008 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by National Institute on Drug Abuse (NIDA):
|
Opiate Addiction Opiate Dependence |
Additional relevant MeSH terms:
|
Opioid-Related Disorders Substance-Related Disorders Mental Disorders Morphine Tramadol Naloxone Analgesics, Opioid Analgesics Sensory System Agents |
Peripheral Nervous System Agents Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents Therapeutic Uses Central Nervous System Depressants Narcotics Narcotic Antagonists |
ClinicalTrials.gov processed this record on June 17, 2013