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The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
Information provided by:
Policlinico Hospital
ClinicalTrials.gov Identifier:
NCT00141440
First received: August 31, 2005
Last updated: December 29, 2009
Last verified: September 2008
History of Changes
  Purpose

The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.


Condition Intervention
Chronic Obstructive Pulmonary Disease
 Procedure: mechanical ventilation

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:
  • Respiratory mechanics, gas exchange [ Time Frame: 2 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Comfort of breathing [ Time Frame: 2 minutes ] [ Designated as safety issue: No ]

Enrollment: 13
Study Start Date: July 2005
Study Completion Date: March 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
COPD patients
 Procedure: mechanical ventilation
evaluated the effect of two different cycling off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease

Detailed Description:

In this study two levels of cycling off criteria at two levels of PEEP and PSV were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.

  Eligibility

Ages Eligible for Study:   16 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Stable COPD patients during invasive mechanical ventilation

Exclusion Criteria:

  • Hemodynamic instability,
  • Paralysis
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00141440

Locations
Italy
Ospedale Sacco
Milano, Italy, 20100
Sponsors and Collaborators
Policlinico Hospital
Investigators
Principal Investigator: davide chiumello, md Policlinico Hospital
Study Chair: Davide Chiumello, MD Policlinico
  More Information

Publications:

Responsible Party: Davide Chiumello, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00141440     History of Changes
Other Study ID Numbers: 1073
Study First Received: August 31, 2005
Last Updated: December 29, 2009
Health Authority: Italy: Ministry of Health

Keywords provided by Policlinico Hospital:
gas exchange
pressure support ventilation
respiratory mechanics
COPD patients

Additional relevant MeSH terms:
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on June 18, 2013