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Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases

This study has been completed.
Sponsor:
Information provided by:
Merck
ClinicalTrials.gov Identifier:
NCT00140985
First received: August 30, 2005
Last updated: November 19, 2009
Last verified: November 2009
History of Changes
  Purpose

Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases.


Condition Intervention Phase
Renal Disorder
 Drug: MK0954, losartan potassium/Duration of Treatment: 20 weeks
Drug: Comparator: amlodipine / Duration of Treatment: 20 weeks
 Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: A Randomized, Parallel, Double Blind Study of Losartan Versus Amlodipine in Patients With Mild to Moderate Hypertension and Chronic Nondiabetic Proteinuric Nephropathy: Evaluation of the Effect on Proteinuria and on the Plasmatic Levels of Growth Factors (TGFß and VEGF)

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Merck:

Primary Outcome Measures:
  • 24h proteinuria

Secondary Outcome Measures:
  • Changes in the plasma and urinary levels of TGF-beta

Enrollment: 97
Study Start Date: February 2000
Study Completion Date: March 2001
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Males or females at least 18 years of age with non-diabetic proteinuric renal diseases
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00140985

Sponsors and Collaborators
Merck
Investigators
Study Director: Medical Monitor Merck
  More Information

No publications provided

Responsible Party: Executive Vice President, Clinical and Quantitative Sciences, Merck & Co., Inc.
ClinicalTrials.gov Identifier: NCT00140985     History of Changes
Other Study ID Numbers: 2005_058, MK0954-213
Study First Received: August 30, 2005
Last Updated: November 19, 2009
Health Authority: Spain: Ministry of Health

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases
Amlodipine
Losartan
Calcium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
 Cardiovascular Agents
Therapeutic Uses
Vasodilator Agents
Antihypertensive Agents
Anti-Arrhythmia Agents
Angiotensin II Type 1 Receptor Blockers
Angiotensin Receptor Antagonists

ClinicalTrials.gov processed this record on May 22, 2013