Mass Treatment T Solium Community Study
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Purpose
Investigators from Cayetano Heredia University and Johns Hopkins University are doing this study. They want to see how people and pigs get infected with a parasite, called cysticercus (known as "pig triquina"). Cysticercus attacks the meat of pigs and the brains of people. In the intestine, the parasite is known as "solitaria". This study is to see how treatment in both people and pigs works to control the disease.
| Condition | Intervention |
|---|---|
|
Intestinal Parasitism |
Drug: Niclosamide |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | The Effect of a Single Control Intervention in the T Solium Life Cycle |
| Estimated Enrollment: | 4200 |
| Study Start Date: | December 2004 |
| Estimated Study Completion Date: | January 2005 |
This is a prospective intervention study to determine the efficacy and persistence of effect over time of a single, chemotherapy intervention in both the human and porcine population. Four villages will be selected to be treated against T solium adult (in humans) and larval forms (in pigs), and two villages will receive no intervention and will serve as control villages. Pigs in control villages will be followed during 3 months only, and then the human and porcine populations will receive the intervention treatment. The effect of this intervention will be measured by the prevalence of infection in pigs and parasitic burden of infected pigs at month 3, 6, 9, and 12.
Eligibility| Ages Eligible for Study: | 2 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- All consenting individuals older than two years living in the study villages (6 endemic communities of the Northern coast of Peru)
Exclusion Criteria:
- Pregnancy (for antiparasitic treatment only).
Contacts and Locations More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00138359 History of Changes |
| Other Study ID Numbers: | 04-043 |
| Study First Received: | August 26, 2005 |
| Last Updated: | August 26, 2010 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
|
T solium, cysticercus, pig triquina, solitaria, intestinal parasites, Niclosamide, tapeworms, Taeniasis |
Additional relevant MeSH terms:
|
Intestinal Diseases, Parasitic Parasitic Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Niclosamide Anticestodal Agents |
Antiplatyhelmintic Agents Anthelmintics Antiparasitic Agents Anti-Infective Agents Therapeutic Uses Pharmacologic Actions Antinematodal Agents |
ClinicalTrials.gov processed this record on May 16, 2013