Bioavailability of Folate From a Mixed Diet Using a Stable Isotope Method
The main objectives of this project are:
- to determine the relative bioavailability of dietary folate from a total diet, compared with synthetic folic acid and
- to determine the bioavailability with a higher precision than previous methods.
The hypothesis is that the bioavailability of dietary folate within a confidence interval of +/-20% can be estimated.
Behavioral: Controlled diet
Behavioral: folic acid supplement
Behavioral: 13C11-labelled folic acid supplement
|Study Design:||Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Parallel Assignment
Primary Purpose: Prevention
|Official Title:||The Relative Bioavailability of Folate From a Mixed Diet Compared to Synthetic Folic Acid Using a Stable Isotope Method|
- Bioavailability based on change in labelled folate concentration in plasma;
- Bioavailability based on change in folate concentration in plasma
- Bioavailability based on change in concentration in plasma homocysteine
|Study Start Date:||May 2005|
|Estimated Study Completion Date:||June 2005|
Folate plays a role in the prevention of certain birth defects and possibly also in prevention of neurocognitive diseases, cancer and cardiovascular disease. The proportion of dietary folate that is absorbed and becomes available for metabolic processes in the body has been estimated between 30 and 98%, but an accurate figure is lacking. Since subjects generally differ a lot in their folate or homocysteine response upon a change in dietary folate intake, the between-person variability in these responses is high. Therefore, bioavailability estimates derived from these responses have large confidence intervals. With this trial the researchers want to determine folate bioavailability with a higher precision than previous trials. A good estimate of folate bioavailability from the general diet is necessary to construct reliable dietary reference intakes for folate.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00130585
|Wageningen, Netherlands, 6700EV|
|Principal Investigator:||Petra Verhoef, Dr.||Wageningen Centre for Food Sciences|
|Principal Investigator:||Martijn Katan, Professor||Wageningen University|