Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-World Study in a London Street
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose and on the background severity of asthma.
The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs.
|Study Design:||Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:||Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-World Study in a London Street|
|Study Start Date:||May 2003|
|Estimated Study Completion Date:||April 2005|
The investigators will recruit 60 nonsmoking asthmatics of mild and of moderate severity. They will be exposed to Oxford St. or to Hyde Park for 2 hours each, at a walking pace. Real time exposure to PM2.5, carbon monoxide and nitrogen dioxide will be made each time. Health outcome measurements will be made before and after exposure to each street. Statistical analyses will be made to examine the effect of diesel exposure on changes in health outcome measures.
|Principal Investigator:||Paul Cullinan, MD||Imperial College London|
|Study Director:||Fan Chung, MD||Imperial College London|
|Principal Investigator:||Mark Nieuwenhuijsen, PhD||Imperial College London|
|Principal Investigator:||Jim Zhang, PhD||Rutgers U & UMDNJ|