Word-Retrieval for Aphasia

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT00125242
First received: July 27, 2005
Last updated: October 6, 2014
Last verified: October 2014
  Purpose

The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools, fruits). The treatment is also designed to be used as a search strategy in instances of word-finding difficulty. The study was devised to evaluate the extent to which treatment increases the ability to recall trained, as well as untrained, words.


Condition Intervention
Aphasia
Language Disorders
Speech Disorders
Behavioral: Semantic Feature Training

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Word-Retrieval for Aphasia: Facilitation of Generalization

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Generalization of word retrieval skills [ Time Frame: 6 weeks following completion of treatment ] [ Designated as safety issue: No ]

Enrollment: 10
Study Start Date: September 2004
Study Completion Date: April 2013
Primary Completion Date: September 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Arm 1
single subject design (24 participants)
Behavioral: Semantic Feature Training
The treatment is designed to stimulate the semantic feature network so that it may serve as not only a mechanism for improving disrupted lexical semantic processing, but also as a compensatory strategy during word retrieval failures.

Detailed Description:

The purpose of the proposed research is to examine the effects of a semantically-oriented treatment on word retrieval in persons with aphasia. The planned investigations are designed to further the development of semantic feature training so that it may serve as not only a mechanism for improving disrupted lexical semantic processing, but also as a compensatory strategy during word retrieval failures. The proposed research will also address the issue of exemplar typicality (Kiran & Thompson, 2003) by examining the effects of training typical versus atypical exemplars of various categories with individuals with different types of aphasia. A series of 24 single subject experimental designs will be conducted in the context of a group design to address the following experimental questions:

  • Will training atypical examples of living and artifact noun categories using semantic feature training result in a significantly different outcome* than training typical examples of living and artifact noun categories?
  • Will training of one category of nouns using semantic feature training result in improved retrieval of untrained categories of nouns?
  • Will effects of semantic feature training vary across aphasia types?
  • Will semantic feature training result in increased production of content during discourse?
  • Will generalization to untrained typical examples vary across generalization lists that are repeatedly exposed and those that are limited in exposure? (i.e., Does repeated exposure appear to contribute to generalization?)

    • Outcome measure will reflect acquisition, response generalization within category, and response generalization across category effects of treatment.
  Eligibility

Ages Eligible for Study:   21 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Diagnosis of Wernicke's, Broca's, or Conduction aphasia with significant word-retrieval deficits
  • At least 6 months post-onset of single, left-hemisphere stroke
  • Minimum of high-school education
  • Visual and auditory acuity sufficient for experimental tasks
  • Nonverbal intelligence within normal limits

Exclusion Criteria:

  • Diagnosed mental illness other than depression
  • Neurological condition other than that which resulted in aphasia
  • History of alcohol or substance abuse
  • Non-native English speaker
  • Premorbid history of speech/language disorder
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00125242

Locations
United States, Utah
VA Salt Lake City Health Care System, Salt Lake City
Salt Lake City, Utah, United States, 84148
Sponsors and Collaborators
Investigators
Principal Investigator: Julie L. Wambaugh, PhD VA Salt Lake City Health Care System, Salt Lake City
  More Information

Publications:
Responsible Party: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00125242     History of Changes
Other Study ID Numbers: C3826-R
Study First Received: July 27, 2005
Last Updated: October 6, 2014
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Aphasia
Language therapy
Rehabilitation of speech and language disorders
Speech-language pathology

Additional relevant MeSH terms:
Aphasia
Disease
Language Disorders
Speech Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Pathologic Processes

ClinicalTrials.gov processed this record on October 19, 2014