Psychotherapy of Generalized Anxiety Disorder
Recruitment status was Active, not recruiting
The purpose of this study is to compare the effects of worry exposure with the effects of applied relaxation in patients with generalized anxiety disorder.
Behavioral: Worry exposure
Behavioral: Applied relaxation
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Worry Exposure Versus Applied Relaxation in the Treatment of Generalized Anxiety Disorder|
- At post-treatment: anxiety (Hamilton Anxiety Rating Scale, HARS), depression (Hamilton Depression Scale, HAM-D), trait-anxiety (State-Trait-Anxiety Inventory, STAI-T)
- At 6-month follow-up: M-CIDI (Composite International Diagnostic Interview, generalized anxiety disorder section)
- At post-treatment, 6 and 12 month follow-ups:
- worry (Penn State Worry Questionnaire, PSWQ)
- general symptoms (Brief Symptom Inventory, BSI)
- depression (Beck Depression Inventory, BDI)
- interpersonal problems (Inventory of Interpersonal Problems – IIP)
- meta-cognitions (Meta Cognitions Questionnaire)
- thought suppression (White Bear Suppression Inventory) tolerance for uncertainty (Ungewissheitstoleranzskala, UGTS)
- positive and negative affect (Positive and Negative Affect Schedule, PANAS)
- At post-treatment: behavior assessment tests
|Study Start Date:||October 2001|
|Estimated Study Completion Date:||July 2006|
Controlled treatment studies show that there is a lower efficacy of cognitive-behavioral treatment of generalized anxiety disorder (GAD) than in other anxiety disorders. The best effect sizes are found for applied relaxation (Öst), but there are only three treatment studies. Another, yet previously not tested in its pure form, approach is "worry-exposure", which aims at confronting the emotionally intensive imaginative contents of worries in GAD.
Fifty-two randomized patients with GAD as a primary diagnosis will be treated with one of the two treatments and will be compared with waiting-list patients. This treatment protocol contains 15 sessions (+/-2) and a 6 month and 12 month follow-up.
The comparisons in this study include: worry exposure versus applied relaxation versus a waiting control group.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00118001
|Technische Universität Dresden|
|Dresden, Germany, 01187|
|Principal Investigator:||Jürgen Hoyer, PhD||Technische Universität Dresden|
|Principal Investigator:||Eni S Becker, PhD||University of Nijmegen|