Escitalopram for the Treatment of Self-Injurious Skin Picking
The purpose of this study is to determine the effectiveness of escitalopram in treating self-injurious skin picking.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Escitalopram for the Treatment of Self-Injurious Skin Picking|
- MGH Skin Picking Scale
- Skin Picking Impact Scale
- Skin Picking Treatment Scale
- Clinical Global Impressions scale
- Hamilton Depression Rating
- Beck Depression Inventory
- Beck Anxiety Inventory
- Quality of Life Enjoyment and Satisfaction Scale
|Study Start Date:||September 2002|
|Study Completion Date:||November 2005|
Purpose: Self-injurious skin picking is a problem documented to occur in 2 % of dermatology patients (Gupta, Gupta and Haberman, 1986) , and approximately 4% of the general population (Keuthen et al., 2000). It is widely under recognized, with medical sequelae that can include scarring, infections, lesions, and potentially life-threatening outcomes (O'Sullivan et al., 1999). In a prior study, fluoxetine was shown to be superior to placebo in treating self-injurious skin picking in a modest-sized double blind trial (Simeon et al., 1997). Similarly, open-label trials of other SSRIs, including sertraline (Kalivas, Kalivas and Gilman, 1996) and fluvoxamine (Arnold et al., 1999) resulted in reductions in skin-picking behavior. Escitalopram is a new SSRI that may have superior efficacy for the treatment of major depression and fewer side effects than other SSRIs. This study aims to assess the efficacy of escitalopram in patients who suffer from self-injurious skin-picking.
Comparisons: Subjects' initial scores on the CGI, HAM-D, SPTS, SPS, SPIS, BDI, BAI, QLESQ, & BDDQ will be compared to subjects' final scores.
|United States, Massachusetts|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Nancy J Keuthen, Ph.D.||Massachusetts General Hospital|