Partner Notification for Chlamydia in Primary Care

This study has been completed.
Sponsor:
Information provided by:
University of Bristol
ClinicalTrials.gov Identifier:
NCT00112255
First received: May 31, 2005
Last updated: May 9, 2006
Last verified: May 2005
  Purpose

The purpose of this study was to compare the effectiveness of partner notification by general practice nurses with referral to a specialist clinic for people with genital chlamydia diagnosed in a community setting. We hypothesised that referral to a specialist would be more effective in ensuring treatment of the sexual partners of infected people than the simpler nurse-led strategy.


Condition Intervention Phase
Chlamydia Infections
Behavioral: Practice nurse-led partner notification
Behavioral: Referral to specialist genitourinary clinic
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Partner Notification for Chlamydia in Primary Care: Randomised Controlled Trial and Economic Evaluation

Resource links provided by NLM:


Further study details as provided by University of Bristol:

Primary Outcome Measures:
  • Percentage of index cases with at least one sexual partner treated
  • Number of sexual partners per index case treated

Secondary Outcome Measures:
  • Number of sexual partners per index case elicited during sexual history taking
  • Positive chlamydia test result six weeks after treatment
  • Adherence to advice to abstain from sexual intercourse until both partners completed treatment

Estimated Enrollment: 214
Study Start Date: March 2001
Estimated Study Completion Date: December 2002
Detailed Description:

Partner notification (contact tracing) is essential to the control of sexually transmitted infections. Reports of new chlamydia infections have increased by 66% in the past five years. A National Chlamydia Screening Programme in England, and increasing primary care provision of sexual health care are part of the United Kingdom Government’s strategy for tackling increasing rates of sexually transmitted infections. New strategies for managing chlamydia in non-specialist settings are urgently required: genitourinary medicine clinics are failing to cope with their increasing workload; and 45% of cases detected in the chlamydia screening pilot studies were diagnosed in general practice.

Partner notification involves informing the sexual partners of someone with a sexually transmitted infection of the possibility of exposure, offering them diagnosis and treatment, and providing advice about preventing future infection. In the United Kingdom, this is usually done by specialist sexual health advisers in departments of genitourinary medicine. The effectiveness of partner notification in non-specialist settings in developed countries is not known. We conducted a randomised controlled trial to compare the effectiveness of practice nurse-led partner notification with referral to a genitourinary clinic for partner notification conducted by a specialist health adviser, and to compare the resources used by each strategy.

Comparisons: Partner notification at the time of receiving diagnosis and treatment by general practice nurses who received a one-day training course and ongoing support by telephone calls or visits from a specialist adviser in sexual health, compared with referral to a genitourinary medicine clinic for partner notification by a specialist adviser in sexual health.

  Eligibility

Ages Eligible for Study:   16 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Chlamydia trachomatis diagnosed through a population-based screening study
  • Chlamydia test result received at patient's general practice
  • Chlamydia cases diagnosed in general practice

Exclusion Criteria:

  • None
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00112255

Locations
United Kingdom
Chlamydia Screening Studies (ClaSS) project general practices
Bristol, Avon, United Kingdom, BS8 2PR
Chlamydia Screening Studies (ClaSS) project general practices
Birmingham, West Midlands, United Kingdom, B15 2TT
Sponsors and Collaborators
University of Bristol
Investigators
Study Director: Nicola Low, MFPH Chlamydia Screening Studies (ClaSS) Project General Practices
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00112255     History of Changes
Other Study ID Numbers: HTA_97/32/31
Study First Received: May 31, 2005
Last Updated: May 9, 2006
Health Authority: United Kingdom: National Health Service

Keywords provided by University of Bristol:
Chlamydia trachomatis
Chlamydia infections
Randomized controlled trials
Contact tracing
Family practice

Additional relevant MeSH terms:
Chlamydia Infections
Chlamydiaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections
Sexually Transmitted Diseases, Bacterial
Sexually Transmitted Diseases
Infection
Genital Diseases, Male
Genital Diseases, Female

ClinicalTrials.gov processed this record on August 20, 2014