ACCLAIM - Advanced Chronic Heart Failure CLinical Assessment of Immune Modulation Therapy

This study has been completed.
Sponsor:
Information provided by:
Vasogen
ClinicalTrials.gov Identifier:
NCT00111969
First received: May 26, 2005
Last updated: June 28, 2006
Last verified: June 2006
  Purpose

The purpose of this study is to test the safety and efficacy of the Celacade™ system in reducing the risk of mortality and cardiovascular hospitalizations in patients with chronic systolic heart failure.


Condition Intervention Phase
Heart Failure, Congestive
Device: Celacade™ system
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: A Multi-Center, Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess the Effects of the Celacade™ System on Mortality and Morbidity in Patients With Chronic Heart Failure

Resource links provided by NLM:


Further study details as provided by Vasogen:

Primary Outcome Measures:
  • Mortality
  • Cardiovascular hospitalization

Secondary Outcome Measures:
  • Clinical status
  • Health-related patient quality
  • Healthcare resource utilization

Estimated Enrollment: 2016
Study Start Date: June 2003
Estimated Study Completion Date: November 2005
Detailed Description:

Evidence continues to accumulate on the importance of inflammation in the development and progression of heart failure (HF). The Celacade™ system may reduce chronic inflammation by stimulating the immune system’s physiological anti-inflammatory response. The ACCLAIM study is an international, approximately 2,000-patient, Phase III clinical research study designed to test the safety and efficacy of the Celacade™ system in reducing the risk of mortality and cardiovascular hospitalizations in patients with chronic systolic HF.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male or female aged 18 or older.
  • New York Heart Association (NYHA) Class II to IV.
  • Left ventricular ejection fraction (LVEF) ≦ 30%, measured within the past six months (by any technique), unless there was a cardiovascular event that could have modified the LVEF during that period (e.g., coronary artery bypass grafting [CABG], myocardial infarction [MI]). If the patient was started on a beta-blocker or biventricular pacing (cardiac resynchronization therapy, or CRT), the LVEF measurement must have been at least three months after starting the therapy.
  • Hospitalized for heart failure; OR, received intravenous (IV) administration of an inotropic agent (therapeutic dose for HF), human B-natriuretic peptide, or IV diuretic (minimum 40 mg of furosemide or equivalent) in a clinic, outpatient or emergency department within the past 12 months (stable for at least 2 weeks). Exceptions: patients in NYHA Class III or IV who have a LVEF of < 25%.
  • On standard therapy for congestive heart failure (CHF), which must include angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blocker (ARB) (unless contraindicated or patient is intolerant), with or without other appropriate agents. If on a beta-blocker, patient must have been on a beta-blocker for at least three months.
  • No changes in active cardiac medications for heart failure during the two weeks prior to randomization.
  • Written informed consent

Exclusion Criteria:

  • Inability to comply with the conditions of the protocol.
  • Presence of a transplanted tissue or organ or left ventricular assist device (LVAD) (or the expectation of the same within the next 12 months).
  • Planned Automatic Implantable Cardiac Defibrillator (AICD) or CRT within the next 12 months.
  • Acute MI, or CABG, percutaneous coronary intervention (PCI), AICD, or CRT within the past three months.
  • Need for chronic intermittent inotropic therapy.
  • Malignancy: evidence of disease within the previous five years. Exceptions: basal cell carcinoma, provided that it is neither infiltrating nor sclerosing, and carcinoma in situ of the cervix.
  • Active myocarditis or early postpartum cardiomyopathy (within the first six months of delivery).
  • Systemic corticosteroids, cytostatics, immunosuppressive drug therapy (cyclophosphamide, methotrexate, cyclosporine, azathioprine, etc.), and DNA depleting or cytotoxic drugs taken within four weeks prior to study treatment.
  • Pregnancy, or patients of childbearing potential not using adequate contraceptive methods.
  • Porphyria.
  • Allergy to sodium citrate or any “caine” type of local anesthetic.
  • Previous Celacade™ treatment.
  • Patient scheduled for hospice care.
  • Clinically relevant abnormal findings in the clinical history, physical examination, electrocardiogram (ECG), or laboratory tests at the screening assessment that would interfere with the objectives of the study or that would, in the investigator’s opinion, preclude safe completion of the study. Abnormal findings could include: known HIV infection or other immunodeficiency state, chronic active viral infection (such as hepatitis B or C), acute systemic infections (defined as patients undergoing treatment with antibiotics), gastrointestinal tract bleeding, or any severe or acute concomitant illness or injury.
  • Any other medical, social, or geographical factor that would make it unlikely that the patient could comply with study procedures (e.g., alcohol abuse, lack of permanent residence, severe depression, disorientation, distant location, or a history of noncompliance).
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00111969

Sponsors and Collaborators
Vasogen
Investigators
Study Director: Andrea B Parker, PhD Vasogen Inc.
  More Information

Additional Information:
No publications provided by Vasogen

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00111969     History of Changes
Obsolete Identifiers: NCT00386295
Other Study ID Numbers: 0202
Study First Received: May 26, 2005
Last Updated: June 28, 2006
Health Authority: United States: Food and Drug Administration
Canada: Health Canada
Germany: Federal Institute for Drugs and Medical Devices
Norway: Norwegian Medicines Agency
Denmark: Danish Medicines Agency
Poland: Ministry of Health
Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Vasogen:
Heart failure
Immune modulation therapy
Inflammation
Chronic systolic heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on September 16, 2014