Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal
The purpose of this study is to determine whether daily supplementation of young children in Nepal with either zinc, iron-folic acid, or both can reduce mortality and morbidity. Young children in Nepal have numerous nutritional deficiencies and high rates of morbidity and mortality. Zinc and/or iron supplementation may be a cost-effective method for reducing these risks.
Drug: zinc sulphate dietary supplement
Drug: iron sulphate-folic acid dietary supplement
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Primary Purpose: Prevention
|Official Title:||Zinc Supplementation Impact on Child Mortality--Nepal|
- Death among children 1-36 months of age
- Incidence rates of selected morbidities including diarrhea, dysentery, acute respiratory infections
|Study Start Date:||October 2001|
|Estimated Study Completion Date:||January 2006|
Mortality rates among preschool age children in Nepal and many other developing countries remain high despite significant progress made over the past 20 years. There remain significant nutritional deficiencies in these populations, especially important are vitamin and mineral deficiencies.
Comparisons: In this study, we are comparing the morbidity and mortality experience for children 1-36 months of age randomized to one of four daily supplementation regimens: placebo, zinc alone, iron-folic acid alone, zinc + iron-folic acid.
|United States, Maryland|
|Johns Hopkins Bloomberg School of Public Health|
|Baltimore, Maryland, United States, 21205-2103|
|United States, New York|
|Cornell University Division of Nutritional Sciences|
|Ithaca, New York, United States, 14853|
|Nepal Nutrition Intervention Project-Sarlahi|
|Kathmandu and Sarlahi District, Nepal|
|Principal Investigator:||James M Tielsch, PhD||Johns Hopkins Bloomberg School of Public Health|