MRS Measurement of Glutamate and GABA Metabolism in Brain
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA)....
|Study Design:||Primary Purpose: Treatment|
|Official Title:||MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain|
|Study Start Date:||April 2005|
Procedure: Magnetic Resonance Spectroscopy
(13)C is a stable (i.e., non-radioactive) isotope of carbon with a natural abundance of approximately 1%. Following infusion of [(13)C]glucose and/or [(13)C]acetate, in vivo MRS (magnetic resonance spectroscopy) can monitor the rate of flux of the (13)C atom from glucose and/or acetate to glutamate to glutamine. Thus, this procedure can provide measure of glutamate (GLU) and glutamine (GLN) turnover in brain. We have established parameters to obtain these measurements in nonhuman primate brain. The current protocol seeks approval to optimize MRS parameters for human brain using the GE 3T, and the Siemens 7T device.
|Contact: Maria D Ferraris Araneta, C.R.N.P.||(301) firstname.lastname@example.org|
|Contact: Robert B Innis, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Robert B Innis, M.D.||National Institute of Mental Health (NIMH)|