Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

This study has been completed.
Sponsor:
Information provided by:
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT00108407
First received: April 14, 2005
Last updated: March 4, 2009
Last verified: March 2009
  Purpose

The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use disorders.


Condition Intervention
Alcohol Abuse
Cannabis Abuse
Major Depressive Disorder
Substance-Related Disorders
Behavioral: Integrated Cognitive Behavioral Therapy
Behavioral: Twelve Step Facilitation Therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Integrated CBT for Substance Use and Depressive Disorders

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Study Start Date: October 2004
Arms Assigned Interventions
Experimental: 1
Integrated Cognitive Behavioral Therapy
Behavioral: Integrated Cognitive Behavioral Therapy
Experimental: 2
Twelve Step Facilitation Therapy
Behavioral: Twelve Step Facilitation Therapy

Detailed Description:

Depression is the most frequent co-occuring mental health disorder among adults with substance use disorders, and such comorbidity is often associated with poorer treatment outcomes. Although there is an urgent need for effective treatments specific for dual-diagnosis adults, few studies have been conducted to address this need.

Comparison: This study will compare substance use and depression symptoms of individuals in two different psychotherapy groups: Integrated Cognitive Behavioral Therapy and Twelve Step Facilitation Therapy. Symptoms and substance use will be compared during the active treatment phase (24 weeks) and for one year following the end of the active treatment.

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Individuals diagnosed with one or more substance use disorders (alcohol, cannabis, and or stimulant abuse/dependence) and an independent co-occurring depressive disorder (major depression or dysthymia) will be included.

Exclusion Criteria:

  • Individuals with substance induced mood disorders and individuals experiencing persistent psychotic symptoms.
  • Those with life threatening or unstable medical illness, neurological disorders, or inability to read will be excluded.
  • Individuals currently prescribed steroids, disulfiram, or long acting benzodiazepines will be excluded.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00108407

Locations
United States, California
VA San Diego Healthcare System, San Diego
San Diego, California, United States, 92161
Sponsors and Collaborators
Investigators
Principal Investigator: Sandra Brown, PhD VA San Diego Healthcare System, San Diego
  More Information

No publications provided by Department of Veterans Affairs

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Brown, Sandra - Principal Investigator, Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00108407     History of Changes
Other Study ID Numbers: MHBS-041-99Sa
Study First Received: April 14, 2005
Last Updated: March 4, 2009
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Alcohol Abuse/Dependence
Alcohol Use Disorders
Cannabis Abuse/Dependence
Depression
Dual diagnosis
Dysthymia
Stimulant Abuse/Dependence
Substance Use Disorders

Additional relevant MeSH terms:
Marijuana Abuse
Depressive Disorder
Depression
Depressive Disorder, Major
Alcoholism
Substance-Related Disorders
Mental Disorders
Mood Disorders
Behavioral Symptoms
Alcohol-Related Disorders

ClinicalTrials.gov processed this record on July 24, 2014