Brain Reaction to Treatment of Nicotine Dependence
The purpose of the study was to determine how the treatments for cigarette craving work.
Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.
|Study Design:||Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Neural Substrates of Treatment for Nicotine Dependence|
- 2-FA PET scan results [ Time Frame: Within the first few weeks of study initiation ] [ Designated as safety issue: No ]Brain activity and activation in response to cigarette-related cues
|Study Start Date:||October 2002|
|Study Completion Date:||June 2011|
|Primary Completion Date:||April 2007 (Final data collection date for primary outcome measure)|
PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.
|United States, California|
|VA Greater Los Angeles Healthcare System, West LA|
|West Los Angeles, California, United States, 90073|
|Principal Investigator:||Arthur L. Brody, MD||VA Greater Los Angeles Healthcare System, West LA|