Trial record 7 of 185 for:    Open Studies | "Developmental Disabilities"

Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2005 by National Institute of Environmental Health Sciences (NIEHS).
Recruitment status was  Recruiting
Sponsor:
Collaborators:
University of California, Davis
University of California, Los Angeles
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00106652
First received: March 28, 2005
Last updated: June 23, 2005
Last verified: March 2005
  Purpose

The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.


Condition
Autism
Developmental Disabilities

Study Type: Observational
Study Design: Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Environmental Factors in the Etiology of Autism

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 2000
Study Start Date: September 2001
Estimated Study Completion Date: September 2006
Detailed Description:

The causes and contributing factors for autism are poorly understood. Evidence suggests that incidence is increasing, but diagnostic changes and improvements may be playing a role. Both genetic and environmental factors appear to play a role. Autopsy studies demonstrate structural changes in the brain and clinical investigations reveal neurophysiologic differences in information processing in autistic versus normal children. Members of our team recently demonstrated altered levels of certain neuropeptides at birth in children who later developed autism.

This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression. This study capitalizes on the strengths of the case-control design, which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial. Comparisons will be made with both general population controls and mentally retarded children.

The aims are to assess the influence of exogenous exposures, the role of susceptibility factors, and the interplay between these two in the etiology of autism and its phenotypic variation. Chemicals with known or suspected neurodevelopmental toxicity, such as PCB’s, certain pesticides, and metals, are being investigated. This study pursues several hypotheses that have recently gained attention, including the combined measles, mumps, rubella vaccine and mercury present in vaccines given during infancy and early childhood. Additionally, biochemical susceptibility is examined through characterization of metabolic, immunologic, and neuronal gene expression profiles and genetic polymorphisms.

  Eligibility

Ages Eligible for Study:   24 Months to 60 Months
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Children between 2 and 5 years old
  • Born in California
  • Parents must speak either English or Spanish
  • Children must be living with at least one biologic parent

Exclusion Criteria:

  • Children not meeting eligibility criteria listed above
  • Children not residing in selected geographical areas (please contact for more information about specific study locations)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00106652

Contacts
Contact: Melissa Rose, B.Sci. (530) 754-8157 mbrose@ucdavis.edu

Locations
United States, California
University of California Recruiting
Davis, California, United States, 95616
Contact: Melissa Rose, B.Sci.    530-754-8157    mbrose@ucdavis.edu   
Principal Investigator: Irva Hertz-Picciotto, MPH, PhD         
Sponsors and Collaborators
University of California, Davis
University of California, Los Angeles
Investigators
Principal Investigator: Isaac N. Pessah, Ph.D. University of California, Davis
Study Director: Irva Hertz-Picciotto, Ph.D. University of California, Davis
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00106652     History of Changes
Other Study ID Numbers: 11269-CP-001, 200210574-4
Study First Received: March 28, 2005
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
autism
neurodevelopment
neurotoxicology
perinatology
teratology

Additional relevant MeSH terms:
Autistic Disorder
Developmental Disabilities
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on September 16, 2014