Osteoarthritis: Weakness From Inflammation - Full Text View

Osteoarthritis: Weakness From Inflammation

This study is currently recruiting participants.
Verified by National Institute on Aging (NIA), September 2007

Sponsored by:	National Institute on Aging (NIA)
Information provided by:	National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:	NCT00104312

Purpose

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Condition

Osteoarthritis

MedlinePlus related topics:

Osteoarthritis

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History

Official Title:	Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Further study details as provided by National Institute on Aging (NIA):

Estimated Enrollment:	60
Study Start Date:	April 2001
Estimated Study Completion Date:	January 2007

Detailed Description:

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Eligibility

Ages Eligible for Study:	50 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

50 years of age or older
Normal body weight (a Body Mass Index (BMI) of 30 or less)
Osteoarthritis of the knee (prior to knee surgery)
Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

History of a stroke
History of muscle weakness or paralysis
History of Rheumatoid Arthritis or
Inflammatory Joint Disease
History of a Bleeding Disorder
History of Gout
Diabetes for which you take insulin
Polymyalgia rheumatica (total body muscle aching/stiffness)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00104312

Contacts


Contact: Edwina Rusch	410-350-3941 or 800-225-2572 ext 3941	ruschew@nia.nih.gov

Locations


United States, Maryland
	Harbor Hospital	Recruiting
	Baltimore, Maryland, United States, 21225
	Contact: Sarah Betkey 410-350-3941 or 800-225-2572 ext 3941 betkeys@grc.nia.nih.gov
	Principal Investigator: Shari Ling, MD

Sponsors and Collaborators

National Institute on Aging (NIA)

Investigators


Principal Investigator:	Shari Ling, MD	NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics

More Information

Publications:

Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA. Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 2000 May;43(5):995-1000.

Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum. 1998 Nov;41(11):1951-9.

Conwit RA, Stashuk D, Tracy B, McHugh M, Brown WF, Metter EJ. The relationship of motor unit size, firing rate and force. Clin Neurophysiol. 1999 Jul;110(7):1270-5.

Study ID Numbers:	AG0016
First Received:	February 24, 2005
Last Updated:	September 19, 2007
ClinicalTrials.gov Identifier:	NCT00104312
Health Authority:	United States: Federal Government

Keywords provided by National Institute on Aging (NIA):

Knee Osteoarthritis

Muscle

Cytokine

Mobility

Function

Study placed in the following topic categories:

Osteoarthritis, Knee

Musculoskeletal Diseases

Asthenia

Osteoarthritis

Joint Diseases

Arthritis

Rheumatic Diseases

Inflammation

Additional relevant MeSH terms:

Pathologic Processes

ClinicalTrials.gov processed this record on July 18, 2008