Osteoarthritis: Weakness From Inflammation

This study has been completed.
Sponsor:
Information provided by:
National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:
NCT00104312
First received: February 24, 2005
Last updated: May 28, 2009
Last verified: May 2009
  Purpose

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.


Condition
Osteoarthritis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Resource links provided by NLM:


Further study details as provided by National Institute on Aging (NIA):

Biospecimen Retention:   Samples Without DNA

Synovial fluid and tissue blood serum muscle biopsy


Estimated Enrollment: 88
Study Start Date: April 2001
Study Completion Date: May 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Participants with symptomatic knee osteoarthritis
2
Participants without symptomatic knee osteoarthritis, age-matched as controls

Detailed Description:

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Community - Men and women

Criteria

Inclusion Criteria:

  • 50 years of age or older
  • Normal body weight (a Body Mass Index (BMI) of 30 or less)
  • Osteoarthritis of the knee (prior to knee surgery)
  • Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

  • History of a stroke
  • History of muscle weakness or paralysis
  • History of Rheumatoid Arthritis or
  • Inflammatory Joint Disease
  • History of a Bleeding Disorder
  • History of Gout
  • Diabetes for which you take insulin
  • Polymyalgia rheumatica (total body muscle aching/stiffness)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00104312

Locations
United States, Maryland
Harbor Hospital
Baltimore, Maryland, United States, 21225
Sponsors and Collaborators
Investigators
Principal Investigator: Shari Ling, MD NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics
  More Information

Publications:
Responsible Party: Shari Ling, MD, Principal Investigator, National Institute on Aging
ClinicalTrials.gov Identifier: NCT00104312     History of Changes
Other Study ID Numbers: AG0016
Study First Received: February 24, 2005
Last Updated: May 28, 2009
Health Authority: United States: Federal Government

Keywords provided by National Institute on Aging (NIA):
Knee Osteoarthritis
Muscle
Cytokine
Mobility
Function

Additional relevant MeSH terms:
Inflammation
Osteoarthritis
Osteoarthritis, Knee
Pathologic Processes
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on July 29, 2014