Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans
The purpose of this study is to determine whether DHEA replacement therapy decreases abdominal fat and improves insulin sensitivity.
|Study Design:||Allocation: Randomized
Primary Purpose: Prevention
|Official Title:||Biologic Effects of DHEA in Humans|
- 6-month change in visceral and subcutaneous abdominal fat
|Study Start Date:||June 2001|
|Study Completion Date:||February 2004|
|Primary Completion Date:||February 2004 (Final data collection date for primary outcome measure)|
Studies on rats and mice have shown that the adrenal hormone dehydroepiandrosterone (DHEA) reduces abdominal visceral fat and protects against insulin resistance. This study was done to learn if DHEA replacement therapy decreases abdominal obesity and improves insulin action in humans.
Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose tolerance tests at the beginning and conclusion of the study. Other tests included measurements of hormones and lipids.
|United States, Missouri|
|Washington University School of Medicine|
|St. Louis, Missouri, United States, 63110|
|Principal Investigator:||John O. Holloszy, MD||Washington University School of Medicine|
|Principal Investigator:||Dennis T. Villareal, MD||Washington University School of Medicine|