A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients

This study has been completed.
Sponsor:
Information provided by:
Institute for Neurodegenerative Disorders
ClinicalTrials.gov Identifier:
NCT00096876
First received: November 16, 2004
Last updated: June 9, 2008
Last verified: June 2008
  Purpose

In this study, individuals complete and return a mail survey, specifically a 40 item scratch and sniff smell test.


Condition
Parkinson Disease
Parkinsonian Syndrome

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Screening Evaluations for Neurologic Syndromes: Olfactory Testing in Relatives of Parkinson's Disease Patients

Resource links provided by NLM:


Further study details as provided by Institute for Neurodegenerative Disorders:

Estimated Enrollment: 600
Study Start Date: October 2004
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Detailed Description:

This study would extend the findings of previous studies by characterizing the performance of the 40-item UPSIT in a cohort of first-degree relatives of Parkinson's disease (PD) patients. The results would also validate the use of the University of Pennsylvania Smell Identification Test (UPSIT) as a mail-survey instrument. Once identified, these individuals could be followed as a potentially at-risk cohort to determine if the screening evaluation was predictive of later developing Parkinson's disease. The results from this pilot study have the potential to guide the use of olfactory testing using the UPSIT as a screening tool, and to provide necessary preliminary data for planning clinical trials to prevent the occurrence of PD in at-risk individuals.

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Subject must be a first-degree relative of a PD patient with diagnosis confirmed by a movement disorders specialist at the Institute for Neurodegenerative Disorders
  • Subject must not carry a diagnosis of PD or other neurodegenerative disorder
  • Subject must be either at least 50 years old or within 10 years of the age of onset of their affected relative
  • Subject must be a non-smoker
  • Subject must have no other known reason for abnormal olfaction (e.g. nasal trauma)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00096876

Locations
United States, Connecticut
Institute for Neurodegenerative Disorders
New Haven, Connecticut, United States, 06510
Sponsors and Collaborators
Institute for Neurodegenerative Disorders
Investigators
Principal Investigator: Danna Jennings, MD Institute for Neurodegenerative Disorders
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00096876     History of Changes
Other Study ID Numbers: SENSOR
Study First Received: November 16, 2004
Last Updated: June 9, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by Institute for Neurodegenerative Disorders:
Parkinsonian syndrome

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases

ClinicalTrials.gov processed this record on July 22, 2014