Comparison of Three Electroconvulsive Therapy (ECT) Techniques for the Treatment of Major Depression
This study will compare the antidepressant benefits and cognitive side effects of three different types of electroconvulsive therapy (ECT) in people with unipolar or bipolar depression.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Comparing Three Electrode Placements to Optimize ECT|
|Study Start Date:||February 2003|
|Primary Completion Date:||May 2006 (Final data collection date for primary outcome measure)|
ECT is an important treatment for severely depressed people who do not respond adequately to, or are intolerant of, antidepressant medication. Traditionally, ECT has been administered with one of two standard techniques: bilateral and right unilateral electrode placement. However, these techniques are limited by either low efficacy or high cognitive impairment. Recently, an additional technique for ECT administration has shown promise in preliminary studies: bifrontal ECT. This study will compare this technique to the two traditional ECT techniques in treating people with depressive symptoms.
Participants in this study will be randomly assigned to receive standard bilateral ECT, high-dose right unilateral ECT, or bifrontal ECT in their index course. Depression symptoms, neuropsychological status, and quality of life will be measured throughout the course of the ECT treatment, one week after, and at a 2-month follow-up visit. This study will run for 4 years.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00069407
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|
|United States, New Jersey|
|Newark, New Jersey, United States, 07103|
|United States, New York|
|Northshore/Long Island Jewish Hillside Hospital|
|Glen Oaks, New York, United States, 11004|
|United States, Texas|
|University of Texas Southwestern Medical Center|
|Dallas, Texas, United States, 75235|