Trial record 12 of 75 for:    Open Studies | "head injuries" NOT (traumatic OR concussion)

Therapy for Reading Problems in Adults After Brain Injury

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2006 by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Recruitment status was  Recruiting
Information provided by:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Identifier:
First received: July 14, 2003
Last updated: September 11, 2008
Last verified: January 2006

Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.

Condition Intervention
Dyslexia, Acquired
Brain Injuries
Cerebrovascular Accident
Behavioral: Cognitive Therapy to Improve Reading

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Cognitively-Based Treatments of Acquired Dyslexias

Resource links provided by NLM:

Further study details as provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):

Primary Outcome Measures:
  • Improved accuracy and/or speed of reading individual words aloud.

Secondary Outcome Measures:
  • Improved accuracy and/or speed of reading text aloud.

Estimated Enrollment: 58
Study Start Date: August 2002
Estimated Study Completion Date: July 2007
Detailed Description:

Acquired disorders of reading (acquired dyslexia) are common in patients with aphasia subsequent to left hemisphere stroke. Even when language functions recover sufficiently to enable the patient to return to work, continuing dyslexia often interferes significantly with job performance. This study will evaluate cognitive therapies for the treatment of acquired dyslexia.

Each therapy is based upon a cognitive neuropsychological model of reading; the therapies target specific types of reading deficit and stem from the question of re-learning versus re-organization of function. The therapies focus on dyslexic disorders stemming from the following underlying deficits: 1) impaired access to the orthographic word form from the visual modality (pure alexia); 2) impaired orthographic/phonologic connections (phonologic/deep dyslexia); and 3) decreased ability to hold phonologic codes in memory (phonologic text alexia).

Participants in this study will undergo a comprehensive and detailed battery of reading and reading-related tests to determine the underlying impairment causing the reading deficit. Based upon the results of these tests, the patient's dyslexic disorder will be characterized and, if appropriate, the patient will be assigned to one of the treatment programs devised specifically for that type of deficit. Treatment programs are evaluated for efficacy by comparing the accuracy and speed of reading pre- and post-treatment.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria

  • Reading deficit subsequent to stroke, traumatic brain injury, brain surgery, or other brain damage
  • Ability to attend 2-3 sessions per week for several months at Georgetown University in Washington, DC

Exclusion Criteria

  • History of developmental dyslexia or learning disabilities
  • Best corrected vision less than 20/40
  • Less than 10 years of formal education
  • Significant memory or comprehension problems
  Contacts and Locations
Please refer to this study by its identifier: NCT00064805

Contact: Sarah F. Snider, MA, SLP
Contact: Nora L. Watson, BS

United States, District of Columbia
Georgetown University Medical Center Recruiting
Washington, District of Columbia, United States, 20057
Sponsors and Collaborators
Principal Investigator: Rhonda B. Friedman, Ph.D. Georgetown University Medical School
  More Information

Additional Information:
Publications: Identifier: NCT00064805     History of Changes
Other Study ID Numbers: R01HD36019
Study First Received: July 14, 2003
Last Updated: September 11, 2008
Health Authority: United States: Federal Government

Keywords provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):
Cognitive therapy
Aphasia therapy
Acquired dyslexia
Phonological deficits
Orthographic deficits
Brain disorders
Brain injury

Additional relevant MeSH terms:
Craniocerebral Trauma
Dyslexia, Acquired
Cerebral Infarction
Brain Injuries
Wounds and Injuries
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Mental Disorders Diagnosed in Childhood
Brain Infarction
Brain Ischemia
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Trauma, Nervous System processed this record on April 20, 2014