Trial record 9 of 377 for:    anxiety disorders [CONDITION] AND NIH [SPONSOR-COLLABORATORS-CLASS] NOT NIMH [ORGANIZATION-NAME]

The Psychobiology of Childhood Temperament

This study is currently recruiting participants.
Verified February 2014 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00060775
First received: May 12, 2003
Last updated: April 11, 2014
Last verified: February 2014
  Purpose

The purpose of this study is to use brain imaging technology to examine brain changes that occur in children when they are exposed to various kinds of emotional tasks and to determine if these changes are related to the child's temperament.

Studies suggest that the risk for developing mood and anxiety disorders in preschool children may be linked to differences in temperament. The relationship between temperament and risk or resilience may reflect the influences of brain activity on behavior at different stages of childhood development. Behavioral inhibition and mood or anxiety disorders have been linked to disturbances in the circuitry of several areas in the brain. However, the involvement of this circuitry in temperament remains unclear. This study will use functional magnetic resonance imaging (fMRI) to examine the function of different parts of the brain in children who have previously undergone temperament studies and have had their temperaments classified.

This study will comprise three clinic visits. At Visit 1, children and their parents will meet with study staff individually and together for psychiatric interviews. Children will undergo a physical examination, medical history, a urine drug test, and practice in an fMRI simulator. Saliva samples will be collected from the children and tests will be given to assess stage of puberty, temperament, intelligence, feelings, experiences, and behavior. Other visits include fMRI scans of the brain and other tasks.


Condition
Mood Disorders
Anxiety Disorders
Adolescents

Study Type: Observational
Official Title: The Psychobiology of Temperament: An fMRI Study

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 980
Study Start Date: May 2003
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   7 Years to 25 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

Age: 7-25

Consent: Can give consent/assent.

IQ: All subjects will have IQ greater than 70.

Psychopathology: All subjects will be free of lifetime history of psychosis and pervasive developmental disorder.

EXCLUSION CRITERIA:

Any chronic or acute medical condition severe enough to interfere with task performance or completion of questionnaires.

Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye, dental braces).

Any current axis I psychiatric disorder necessitating acute treatment.

Claustrophobia

Pregnancy

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00060775

Contacts
Contact: Anastasia L McGlade Not Listed anastasia.mcglade@nih.gov
Contact: Daniel S Pine, M.D. (301) 594-1318 pined@mail.nih.gov

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010    prpl@mail.cc.nih.gov   
University of Maryland, College Park Recruiting
College Park, Maryland, United States
Sponsors and Collaborators
Investigators
Principal Investigator: Daniel S Pine, M.D. National Institute of Mental Health (NIMH)
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT00060775     History of Changes
Other Study ID Numbers: 030186, 03-M-0186
Study First Received: May 12, 2003
Last Updated: April 11, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Anxiety
Magnetic Resonance Imaging
fMRI
Emotion
Children
Adolescence
Affective Neuroscience
Neuroimaging
Behavioral Inhibition
Depression
Normal Volunteers
Healthy Volunteer
HV

Additional relevant MeSH terms:
Anxiety Disorders
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on April 17, 2014