Mental Effort and Muscle Strength

This study has been withdrawn prior to enrollment.
(Study terminated/withdrawn)
Sponsor:
Information provided by:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ClinicalTrials.gov Identifier:
NCT00059436
First received: April 25, 2003
Last updated: May 20, 2011
Last verified: May 2011
  Purpose

The purpose of this study is to determine the effect of mental effort on improving muscle strength.


Condition Intervention Phase
Aging
Muscle Strength
Behavioral: Mental effort in muscle strengthening
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Mental-effort Effect on Large Muscle Strengthening

Further study details as provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):

Study Start Date: October 1999
Estimated Study Completion Date: May 2003
Detailed Description:

Training that involves heavy loads or resistance strengthens muscles. Recent data suggest that substantial voluntary strength gains can be achieved with training involving low resistance and strong mental effort. In contrast, individuals who train with the same low intensity contractions but with low mental effort show no improvement in strength.

This study will evaluate the relationship between mental effort muscle strength improvements by comparing the improvement in muscle strength in participants who have trained with different levels of mental effort. In addition to evaluating muscle strength, this study will also examine the neural mechanisms underlying muscle strength improvements.

Four groups of volunteers (65 years old and over) will participate in a training program directed at elbow-flexor muscles. One group will be trained with an intensity near the level of maximal voluntary contraction (MVC group); a second group will be trained with high mental effort, low muscle intensity contractions (HME group); a third group will be trained with low mental effort, low muscle intensity elbow-flexion contractions (LME group); and the fourth (control) group will not be trained but will participate in the strength tests. Training will be performed every weekday for 12 weeks. Participants will be evaluated by functional MRI (fMRI), EEG-derived motor activity-related cortical potential (MRCP), surface EMG signals, and the MRI T2 relaxation time.

Preliminary analysis of results shows that the HME group gained more than 13% strength, the LME group showed a statistically insignificant 6% change, and the no-practice control group did not show any change in elbow flexor muscle strength. We expect the MVC group to have the highest strength gains among the four groups.

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria

  • Healthy individuals free of neurological impairment

Exclusion Criteria

  • Already involved in regular physical training
  • Neuromuscular disorders
  • Medications known to affect neuromuscular system (other than moderate alcohol or caffeine)
  • Left-hand dominant
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00059436

Locations
United States, Ohio
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Sponsors and Collaborators
Investigators
Principal Investigator: Guang H. Yue, Ph.D. Cleveland Clinic Foundation, Biomedical Engineering
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00059436     History of Changes
Other Study ID Numbers: 1R01 HD36725
Study First Received: April 25, 2003
Last Updated: May 20, 2011
Health Authority: United States: Federal Government

Keywords provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):
Muscle strengthening
Skeletal muscle Contractions
Rehabilitative exercise

ClinicalTrials.gov processed this record on April 17, 2014