This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.

• Barrett's Esophagus
• Esophageal Neoplasm

Eligible cases will be defined as those patients and their family members who meet the following criteria:

• Barrett’s esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.
• Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.
• Ability to give informed consent, if patient is age 18 or older.
• No history of radiation to the chest or abdomen.
• No history of chemotherapy in the year preceding the initial diagnosis of Barrett’s esophagus or esophageal adenocarcinoma.