Safety and Efficacy of Doxorubicin Adsorbed to Magnetic Beads

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2003 by FeRx.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
FeRx
ClinicalTrials.gov Identifier:
NCT00054951
First received: February 13, 2003
Last updated: June 23, 2005
Last verified: September 2003
  Purpose

MTC-DOX is Doxorubicin or DOX, a chemotherapy drug, that is adsorbed, or made to “stick,” to magnetic beads (MTCs). MTCs are tiny, microscopic particles of iron and carbon. When DOX is added to MTCs, DOX attaches to the carbon part of the MTCs. MTC-DOX is directed to and deposited in the area of a tumor, where it is thought that it then “leaks” through the blood vessel walls. Once in the surrounding tissues, it is thought that Doxorubicin becomes “free from” the magnetic beads and will then be able to act against the tumor cells. The iron component of the particle has magnetic properties making it possible to direct MTC-DOX to specific tumor sites in the liver by placing a magnet on the body surface. It is hoped that MTC-DOX used with the magnet may target the chemotherapy directly to liver tumors and provide a treatment to patients with liver cancer.

Patients enrolled in the study will be administered MTC-DOX through a hepatic artery catheter inserted under radiological guidance. During and following injection of the MTC-DOX, the drug will be localized to the hepatic tumor site by use of an external magnet. Dose may be divided in order to localize MTC-DOX to all lesions. The MTC-DOX intrahepatic infusions will be repeated every three weeks until tumor progression, complete remission, unacceptable toxicity, or a maximum of six treatment cycles.

The purpose of this Phase 1/2 study is to evaluate time to disease progression following administration of MTC-DOX.


Condition Intervention Phase
Hepatocellular Carcinoma
Drug: MTC-DOX for Injection
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase I/II, Open Label, Multicenter, Single-Arm, Safety and Efficacy Study of Doxorubicin Hydrochloride Adsorbed to Magnetic Targeted Carriers (MTC-DOX) Administered by Intrahepatic Delivery (Via Hepatic Artery Catheterization) for the Treatment of Patients With Unresectable Hepatocellular Carcinoma.

Resource links provided by NLM:


Further study details as provided by FeRx:

Estimated Enrollment: 30
Study Start Date: June 2001
  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Patients may be enrolled into this protocol only if all of the following inclusion criteria are met:

  • Patient has unresectable hepatocellular carcinoma diagnosed by CT scan and meets criteria described in Section 23.
  • Total combined cross-sectional area of all hepatic tumors as determined by CT scan is between 4 and 150 cm2.
  • The center of the tumor(s) mass must be less than or equal to 14 cm from the anterior lateral abdominal wall as determined by cross-sectional imaging at baseline. This is required for optimal placement of the magnet. If more than one tumor mass is present, all of the tumor masses must meet this criterion.
  • Patient is ambulatory with a Karnofsky performance status score greater than or equal to 60 and an estimated life expectancy of greater than or equal to 3 months.
  • Patient is between 18 and 80 years old.
  • Patient is judged by the investigator to have the initiative and means to be compliant with the protocol and be within geographical proximity to allow follow-up.
  • Patient or legal representative has the ability to give informed written consent prior to initiation of therapy.
  • If patient is female and of childbearing potential, she must have a negative b-HCG prior to receiving treatment.
  • Patient must agree to use an effective method of contraception (e.g., birth control pills, condoms, intrauterine device, diaphragm, Norplant, Depo-Provera).

Patients will be excluded from enrollment if any of the following apply:

  • Patient has a history of cancer other than hepatocellular (excluding resected basal cell carcinoma; or curatively resected stage 1 or less cervical cancer if disease free for 5 years or more).
  • Patient has had prior radiation therapy within the last 6 months or chemotherapy within the last 4 weeks.
  • Patients with diffuse hepatocellular carcinoma or disease that precludes delivery of the drug to the tumor via a vessel that feeds the tumor.
  • Patient has another active medical condition(s) or organ disease(s) that may either compromise patient safety or interfere with the safety and/or outcome (e.g., survival) evaluation of the study drugs. While this exclusion is not limited to the following abnormalities, if any of the following laboratory abnormalities are present, the patient should be excluded:

WBC < 3,500/uL Platelets < 40,000/ul Hemoglobin < 9.5 gm/dL Total bilirubin > 2.5 mg/dL ALT or AST > or equal to 5 x upper limit of normal Serum Creatinine > 2.0 mg/dL INR > or equal to 2.0

  • Patient has cardiac dysfunction with a left ventricular ejection fraction < 40%.
  • Patient or physician plans concomitant chemotherapy, radiation therapy, hormonal and/or biological treatment for cancer including immunotherapy (excluding megace, oral contraceptives or post menopausal estrogen replacement therapy) while on study.
  • Patients with an indwelling cardiac pacemaker, cerebral aneurysm clips, or any other indwelling device or appliance that could be adversely affected by the use of the external magnet.
  • Patients with documented evidence of hemachromatosis or hemosiderosis.
  • Patients with CT or Ultrasound evidence of main or first branch portal vein invasion or thrombosis.
  • Prior orthotopic hepatic transplant.
  • Patient has received previous treatment with doxorubicin, idarubicin, and/or other anthracyclines or anthracenes.
  • Patient has a known allergy to doxorubicin, MTC-DOX or any of their components.
  • Patient has been treated with any investigational drug, investigational biologic, or investigational therapeutic device within 30 days of initiating study treatment.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00054951

Locations
China
Cancer Institute & Hosp. CAMS
Beijing, China
Chinese PLA Cancer Ctr. Yang Gongjing
Nanjing City, China
Zhong Shan Hospital, Fudan University
Shanghai, China
Sponsors and Collaborators
FeRx
Investigators
Study Director: Joy Koda, Ph. D. VP Clinical Development
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00054951     History of Changes
Other Study ID Numbers: MTC-DOX-006
Study First Received: February 13, 2003
Last Updated: June 23, 2005
Health Authority: United States: Food and Drug Administration

Keywords provided by FeRx:
Hepatoma
Liver Cancer

Additional relevant MeSH terms:
Carcinoma
Carcinoma, Hepatocellular
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Adenocarcinoma
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases
Doxorubicin
Antibiotics, Antineoplastic
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on September 11, 2014