Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3 of cases. The goal of this study is to identify markers that predict the outcome of variocele correction. This would offer considerable health cost savings.
Based on preliminary findings, we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium, a toxic metal, and expression of genes required for normal sperm function. The semen and biopsies will be obtained during clinically dictated procedures. Cadmium and gene expression will be compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
Procedure: Varicocele repair
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
|Official Title:||Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum)|
|United States, New Jersey|
|University of Medicine and Dentistry of NJ, Robert Wood Johnson Medical School at Camden|
|Camden, New Jersey, United States, 08103|
|United States, New York|
|North Shore University Hospital|
|Manhasset, New York, United States, 11030|
|Principal Investigator:||Susan H Benoff, PhD||North Shore University Hospital|