Pyroxamide in Treating Patients With Advanced Cancer

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed solid tumor or hematologic malignancy

  • Disease that has failed standard therapies (e.g., surgery, radiotherapy, endocrine therapy, or chemotherapy) or for which no curative or life- prolonging therapy is available

• Measurable or clinically evaluable disease

  • Elevated tumor marker is acceptable for evaluable disease
• No known carcinomatous meningitis, primary brain tumors, or metastatic brain disease

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 125,000/mm^3
• Hemoglobin at least 9.0 g/dL

Hepatic

• Bilirubin normal
• AST no greater than 2.5 times upper limit of normal (ULN) (5 times ULN if liver metastases present)
• PT no greater than 1.5 times ULN

Renal

• Creatinine normal

Other

• HIV-positive status allowed
• Prior malignancy allowed
• No severe physical or emotional illness that would preclude study participation
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No concurrent bone marrow growth factors

Chemotherapy

• See Disease Characteristics
• At least 4 weeks since prior myelosuppressive chemotherapy (6 weeks for nitrosoureas or mitomycin)

Endocrine therapy

• See Disease Characteristics

Radiotherapy

• See Disease Characteristics
• At least 4 weeks since prior wide-field radiotherapy and recovered
• At least 2 weeks since prior limited-field radiotherapy and recovered
• Recovered from prior radiotherapy

Surgery

• See Disease Characteristics

Other

• No other concurrent antitumor treatment