Socio-Economic Status and Age-Related Disability in a Biracial Community

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2006 by National Institute of Environmental Health Sciences (NIEHS).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00042133
First received: July 24, 2002
Last updated: February 1, 2006
Last verified: February 2006
  Purpose

The overall goal of the proposed project is to examine the reasons for the higher levels of disability in older people of lower socio-economic status.


Condition
Healthy

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 6000
Study Start Date: April 2001
Estimated Study Completion Date: August 2010
Detailed Description:

This application is a continuation of an epidemiologic study that investigates the effect of socio-economic disadvantage and neighborhood conditions on disability in older blacks and whites. The proposed project takes place in the context of a population-based, longitudinal study of persons aged 65 years and over who live in a geographically defined, urban, biracial community area in Chicago. During the initial funding period, we have successfully collected yearly disability outcome data, and detailed information on neighborhood conditions using self-report instruments and a systematic neighborhood survey of study area.

The first overall goal of this continuation is to determine the relative contribution and specific nature of the neighborhood conditions that are associated with disability in older adults. The second overall goal is to determine the biological mechanisms through which neighborhood conditions lead to increased disability, focusing specifically on hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, via salivary cortisol, and inflammatory processes, via interleukin-6 (IL-6) and C-reactive protein (CRP), obtained from blood samples. To accomplish these goals, we propose to continue yearly collection of disability outcome data and obtain blood samples and salivary cortisol from over 7,000 participants. These data will be integrated with a rich set of existing data on personal characteristics, health conditions, and neighborhood factors to test of series of specific hypotheses related to the overall goals.

Disability is a common and highly prevalent consequence of age-related chronic diseases, and a critical indicator of overall health among older people. Prevention of disability is essential to improve the lives of older people and reduce health care costs. The proposed work will contribute to a better understanding of the specific neighborhood conditions that are associated with increased disability, laying the foundation for more effective policies to prevent disability in future generations of older adults.

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

inclusion criteria: adults aged 65 years and over exclusion criteria: none

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00042133

Contacts
Contact: Jennifer Tarpey 312-942-3350 jtarpey@rush.edu
Contact: Carlos F. Mendes de Leon, Ph.D. (312) 942-3350 cmendes@rush.edu

Locations
United States, Illinois
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Carlos F. Mendes de Leon, Ph.D.    312-942-3350    cmendes@rush.edu   
Contact: Denis A. Evans, M.D.    312-942-3350      
Principal Investigator: Carlos F. Mendes de Leon, Ph.D.         
Sub-Investigator: Denis A. Evans, M.D.         
Sub-Investigator: Julia L. Bienias, Sc.D.         
Sub-Investigator: Lisa L. Barnes, Ph.D.         
Sub-Investigator: Susan A. Everson-Rose, Ph.D.         
Sub-Investigator: Jeremiah F. Kelly, M.D.         
Sub-Investigator: Paul A. Scherr, Ph.D., D.Sc.         
Sub-Investigator: Kathleen A. Cagney, Ph.D.         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Sponsors and Collaborators
Investigators
Principal Investigator: Carlos F. Mendes de Leon, Ph.D. Rush University Medical Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00042133     History of Changes
Other Study ID Numbers: 10902-CP-001
Study First Received: July 24, 2002
Last Updated: February 1, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
aging
disability
longitudinal studies
neighborhood factors
socio-economic status
race

ClinicalTrials.gov processed this record on July 28, 2014