Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity - Full Text View

Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

This study has been completed.

Sponsored by:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00041821

Purpose

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Condition	Intervention
Rhinitis, Allergic, Nonseasonal	Procedure: Nasal irritation thresholds and irritant provocation

MedlinePlus related topics:

Allergy

Drug Information available for:

Salicylsalicylic acid Sodium salicylate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Randomized, Single Blind, Crossover Assignment

Official Title:	Individual Factors in Nasal Irritant Sensitivity

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	64
Study Start Date:	September 2000

Eligibility

Ages Eligible for Study:	18 Years to 69 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Non-smokers
18-69 years of age
With or without allergic rhinitis (hay fever)
In good general health and with no prior history of asthma

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00041821

Locations


United States, California
	Upper Airway Biology Laboratory
	Richmond, California, United States, 94804

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

More Information

Website of UCSF Upper Airway Biology Laboratory This link exits the ClinicalTrials.gov site

Publications:

Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40.

Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9.

Study ID Numbers:	10424-CP-001
First Received:	July 18, 2002
Last Updated:	March 22, 2006
ClinicalTrials.gov Identifier:	NCT00041821
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

rhinitis

irritation

trigeminal

Study placed in the following topic categories:

Hypersensitivity

Otorhinolaryngologic Diseases

Respiratory Tract Infections

Respiratory Tract Diseases

Rhinitis, Allergic, Perennial

Salicylsalicylic acid

Sodium Salicylate

Hypersensitivity, Immediate

Rhinitis

Respiratory Hypersensitivity

Additional relevant MeSH terms:

Immune System Diseases

Nose Diseases

ClinicalTrials.gov processed this record on November 20, 2008