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Phase 2 Study of TLK286 Administered Weekly in Advanced Non-Small Cell Lung Cancer

This study has been completed.

Sponsored by: Telik
Information provided by: Telik
ClinicalTrials.gov Identifier: NCT00040638
  Purpose

The purpose of this study is to determine the effectiveness of TLK286 in the treatment of advanced non-small cell lung cancer.


Condition Intervention Phase
Carcinoma, Non-Small-Cell Lung
 Drug: TLK286
 Phase II

MedlinePlus related topics:   Cancer    Lung Cancer   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study

Further study details as provided by Telik:

Estimated Enrollment:   40

  Eligibility
Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Inclusion Criteria:

  • Histologic or cytologic diagnosis of non-small cell lung carcinoma
  • Progressed while on or after treatment on platinum-based regimen
  • Patients may not have had more than one prior cytotoxic chemotherapy regimen
  • Stage IV or IIIB
  • Age at least 18 years
  • Adequate liver and kidney function
  • Adequate bone marrow function

Exclusion Criteria:

  • Pregnancy or lactation
  • Unstable medical conditions
  • Chemotherapy, hormonal therapy, radiotherapy, radiopharmaceuticals or immunotherapy within 3 weeks of TLK286
  • CNS metastasis unless controlled by treatment
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00040638

Locations
United States, Arizona
Arizona Cancer Center    
      Tucson, Arizona, United States, 85724
United States, California
UCLA Medical Center    
      Los Angeles, California, United States, 90095
United States, Texas
M.D. Anderson Cancer Center    
      Houston, Texas, United States, 77030

Sponsors and Collaborators
Telik
  More Information


Study ID Numbers:   TLK286.2014
First Received:   July 2, 2002
Last Updated:   January 10, 2008
ClinicalTrials.gov Identifier:   NCT00040638
Health Authority:   United States: Food and Drug Administration

Study placed in the following topic categories:
Thoracic Neoplasms
Non-small cell lung cancer
Respiratory Tract Diseases
Lung Neoplasms
Lung Diseases
Carcinoma, Non-Small-Cell Lung
Neoplasms, Glandular and Epithelial
Carcinoma

Additional relevant MeSH terms:
Respiratory Tract Neoplasms
Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on November 20, 2008

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