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Genome Scan for Obesity in a Multi-Ethnic Sample

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00037271
First received: May 16, 2002
Last updated: June 23, 2005
Last verified: August 2004
  Purpose

To scan the genome for obesity in a multi-ethnic sample.


Condition
Cardiovascular Diseases
Heart Diseases
Obesity

Study Type: Observational
Study Design: Observational Model: Defined Population

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: April 2001
Estimated Study Completion Date: March 2003
Detailed Description:

BACKGROUND:

Despite intensive efforts the genetic basis of obesity has been difficult to establish. Linkage analysis using a genome-wide scan can potentially identify genomic regions not previously thought to be associated with susceptibility to obesity and provides a comprehensive test of the consistency of previous studies. The study used the considerable resources generated by the four cooperating networks in the NHLBI-supported "Family Blood Pressure Program" (FBPP) to conduct a genome-wide scan data for obesity.

DESIGN NARRATIVE:

In the Family Blood Pressure Program, microsatellite markers were typed at a density of -10cM by the Mammalian Genotyping Service (MGS) in Marshfield, WI. The complete data set was to include 9,940 individuals representing 4 ethnic groups (white, black, Hispanic and Asian). Obesity was characterized as a weight/height ratio (body mass index) and waist/hip ratio. This data set was larger than any prior genome scan for obesity, and the inclusion of multiple ethnic groups made it possible to examine genetic heterogeneity. The specific aims of the study were to conduct linkage and association analyses to localize regions influencing obesity. Investigators worked closely with the FBPP Coordinating Center (Washington University, St. Louis) and investigators from each of the four FBPP networks. Evidence was sought for consistency between results obtained from analyses of the genome scan performed by each of the individuals, and results summarized from the literature, with those found in meta-analysis.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00037271     History of Changes
Other Study ID Numbers: 1158
Study First Received: May 16, 2002
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Obesity
Body Weight
Nutrition Disorders
Overnutrition
Overweight
Signs and Symptoms

ClinicalTrials.gov processed this record on November 20, 2014