Inclusion Criteria:

• Pancreas cancer that cannot be removed by surgery OR that has spread to a new site in your body.
• You must have one tumor that can be physically measured or scanned by the doctor.
• You have not had any chemotherapy, immunotherapy, biologic therapy, or hormonal therapy for pancreas cancer, including 5-FU.
• You cannot have any radiation for 4 weeks before starting this study, and you cannot have radiation to the whole pelvis.

Exclusion Criteria:

• Treatment with any medication or device that has not been approved by regulatory agencies, like the FDA, at the time you enter the study.
• Documentation that the cancer has spread to your brain.
• Pregnant or breastfeeding.
• A second primary cancer.
• Unable to stop aspirin or non-steroidal anti-inflammatory agents (like ibuprofen) for 5-8 days.