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Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)

ClinicalTrials.gov Identifier:
NCT00032890
First received: April 5, 2002
Last updated: January 20, 2009
Last verified: November 2006
  Purpose

This study will determine whether glucosamine, chondroitin sulfate and/or the combination of glucosamine and chondroitin sulfate are more effective than placebo and whether the combination is more effective than glucosamine or chondroitin sulfate alone in the treatment of knee pain associated with osteoarthritis (OA) of the knee after six months of follow-up. These substances, marketed in the United States as dietary supplements, have been widely touted by the lay press and by anecdotal personal experience as effective in treating OA. To date, however, only a few small studies have been published in the worldwide literature. The study proposed herein has been carefully constructed to definitively determine the efficacy of these agents.


Condition Intervention Phase
Osteoarthritis
Drug: glucosamine
Drug: chondroitin sulfate
Drug: glucosamine and chondroitin sulfate combined
Drug: celecoxib
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Estimated Enrollment: 1588
Study Start Date: April 2000
Estimated Study Completion Date: February 2004
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   40 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

40 years and above, both genders, who have clinical and radiographic osteoarthritis symptomatic for at least six months.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00032890

Locations
United States, Alabama
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294-7201
United States, Arizona
*University of Arizona Arthritis Center
Tucson, Arizona, United States, 85724
United States, California
*Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
*University of California, Los Angeles
Los Angeles, California, United States, 90095
*University of California San Francisco
San Francisco, California, United States, 94110
United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
United States, Indiana
*Indiana University School of Medicine
Indianapolis, Indiana, United States, 46202-5103
United States, Kansas
*Arthritis Research and Clinical Centers
Wichita, Kansas, United States, 67214
United States, Nebraska
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198-3025
United States, New York
Hospital for Joint Diseases
New York, New York, United States, 10003
United States, Ohio
*Case Western Reserve University
Beachwood, Ohio, United States, 44122
United States, Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
*University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, Texas
Arthritis Consultation Center
Dallas, Texas, United States, 75231-4496
United States, Utah
*University of Utah
Salt Lake City, Utah, United States, 84132
United States, Washington
Virginia Mason Research Center
Seattle, Washington, United States, 98101
Sponsors and Collaborators
  More Information

Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00032890     History of Changes
Obsolete Identifiers: NCT00010790
Other Study ID Numbers: GAIT
Study First Received: April 5, 2002
Last Updated: January 20, 2009
Health Authority: United States: Food and Drug Administration

Keywords provided by Department of Veterans Affairs:
osteoarthritis
knee pain

Additional relevant MeSH terms:
Osteoarthritis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on November 19, 2014