DISEASE CHARACTERISTICS:

• Smoked more than 20 pack years
• Evidence of airflow obstruction (FEV_1 less than 80%)
• No end-stage respiratory disease (e.g., FEV_1 less than 0.8 liters, or resting or exertional hypoxemia)

PATIENT CHARACTERISTICS:

Age:

• Over 45

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• No history of liver dysfunction

Renal:

• No renal dysfunction

Cardiovascular:

• No hypertension
• No cardiac condition aggravated by fluid retention and edema
• No unstable angina

Pulmonary:

• See Disease Characteristics

Other:

• Not pregnant
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 7 days after study participation
• No malignancy
• No hypersensitivity to celecoxib
• No allergic reaction to sulfonamides
• No prior allergic reaction (urticaria or asthma) to aspirin or other NSAIDs
• No prior gastrointestinal ulceration, bleeding, or perforation
• No concurrent medical condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• Not specified

Endocrine therapy:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• Not specified

Other:

• No concurrent non-steroidal anti-inflammatory drugs (NSAIDs)
• No concurrent medication known to alter or be affected by alteration of the hepatic p450 2C9 and 2D6 enzymes (e.g., rifampin, fluconazole, fluvastatin, zafirlukast, sulfaphenazole, cimetidine, fluoxetine, paroxetine, quinidine, amiodarone, or ritonavir)