Stereotactic Radiosurgery in Treating Patients With Brain Tumors
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. PURPOSE: Phase I trial to study the effectiveness of stereotactic radiosurgery in treating patients who have brain tumors.
Adult Central Nervous System Germ Cell Tumor
Adult Malignant Meningioma
Adult Noninfiltrating Astrocytoma
Adult Pineal Parenchymal Tumor
Adult Brain Stem Glioma
Adult Infiltrating Astrocytoma
Stage IV Peripheral Primitive Neuroectodermal Tumor
Procedure: Sterotactic radiosurgery
|Study Design:||Primary Purpose: Treatment|
|Official Title:||Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms|
|Study Start Date:||November 1998|
|Study Completion Date:||May 2002|
OBJECTIVES: I. Establish stereotaxic radiosurgery as a treatment technique at the National Institute of Health in patients with intracranial neoplasms.
II. Assess the response rate, local control, time to progression, pattern of failure, and magnetic resonance spectrographic data following this therapy in these patients.
PROTOCOL OUTLINE: All patients undergo stereotaxic head frame placement, followed by stereotaxic radiosurgery on day 1. The dosage of radiation therapy administered is dependent on the tumor diameter.
Patients are followed at 2 and 6 weeks and then every 3 months for 5 years.
Up to 30 patients will be accrued for this study within 7-10 months.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00019578
|United States, Maryland|
|Radiation Oncology Branch|
|Bethesda, Maryland, United States, 20892|
|Study Chair:||Brian G. Fuller||National Cancer Institute (NCI)|