Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

This study has been completed.
Sponsor:
Information provided by:
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT00018785
First received: July 3, 2001
Last updated: January 20, 2009
Last verified: December 2004
  Purpose

Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired immunological tolerance) is a desirable therapeutic option. This project extends recent observations supporting the use of concommitant donor bone marrow cell infusion as a means of modulating the immune response in kidney transplantation, thereby allowing a substantial decrease or withdrawal of potentially toxic immunosuppressive drugs.


Condition Intervention
Kidney Disease
Procedure: donor bone marrow infusion

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Study Start Date: October 1998
Estimated Study Completion Date: September 2003
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Living related donor kidney transplant recipients and the living related donors.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018785

Locations
United States, Florida
VAMC Miami
Miami, Florida, United States, 33125
Sponsors and Collaborators
Investigators
Investigator: Camillo Ricordi, M.D.
Investigator: Andreas Tzakis, M.D.
Investigator: Violet Esquenazi, Ph.D.
Investigator: Keith Zucker, Ph.D.
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00018785     History of Changes
Other Study ID Numbers: IMMU-035-98S
Study First Received: July 3, 2001
Last Updated: January 20, 2009
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
kidney transplantation
immunosuppression
bone marrow

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on July 20, 2014